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- W3206993391 abstract "Near-IR (NIR) light-responsive multimodal nanotherapeutics have been proposed to achieve improved therapeutic efficacy and high specificity in cancer therapy. However, their clinical application is still elusive due to poor biometabolization and short retention at the target site. Here, innovative photoactivatable vanadium-doped adhesive proteinic nanoparticles (NPs) capable of allowing biological photoabsorption and NIR-responsive anticancer therapeutic effects to realize trimodal photothermal-gas-chemo-therapy treatments in a highly biocompatible, site-specific manner are proposed. The photoactivatable tumor-adhesive proteinic NPs can enable efficient photothermal conversion via tunicate-inspired catechol-vanadium complexes as well as prolonged tumor retention by virtue of mussel protein-driven distinctive adhesiveness. The incorporation of a thermo-sensitive nitric oxide donor and doxorubicin into the photoactivatable adhesive proteinic NPs leads to synergistic anticancer therapeutic effects as a result of photothermal-triggered bomb-like multimodal actions. Thus, this protein-based phototherapeutic tumor-adhesive NPs have great potential as a spatiotemporally controllable therapeutic system to accomplish effective therapeutic implications for the complete ablation of cancer." @default.
- W3206993391 created "2021-10-25" @default.
- W3206993391 creator A5034174113 @default.
- W3206993391 creator A5042754076 @default.
- W3206993391 creator A5046235310 @default.
- W3206993391 creator A5068088811 @default.
- W3206993391 creator A5083066637 @default.
- W3206993391 date "2021-10-19" @default.
- W3206993391 modified "2023-10-03" @default.
- W3206993391 title "Tunicate‐Inspired Photoactivatable Proteinic Nanobombs for Tumor‐Adhesive Multimodal Therapy" @default.
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