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• W3206997673 abstract "Emotion dysregulation is central to the development and maintenance of psychopathology, and is common across many psychiatric disorders. Neurobiological models of emotion dysregulation involve the fronto-limbic brain network, including in particular the amygdala and prefrontal cortex (PFC). Neural variability has recently been suggested as an index of cognitive flexibility. We hypothesized that within-subject neural variability in the fronto-limbic network would be related to inter-individual variation in emotion dysregulation in the context of low affective control. In a multi-site cohort (N = 166, 93 females) of healthy individuals and individuals with emotional dysregulation (attention deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), and borderline personality disorder (BPD)), we applied partial least squares (PLS), a multivariate data-driven technique, to derive latent components yielding maximal covariance between blood-oxygen level-dependent (BOLD) signal variability at rest and emotion dysregulation, as expressed by affective lability, depression and mania scores. PLS revealed one significant latent component (r = 0.62, p = 0.044), whereby greater emotion dysregulation was associated with increased neural variability in the amygdala, hippocampus, ventromedial, dorsomedial and dorsolateral PFC, insula and motor cortex, and decreased neural variability in occipital regions. This spatial pattern bears a striking resemblance to the fronto-limbic network, which is thought to subserve emotion regulation, and is impaired in individuals with ADHD, BD, and BPD. Our work supports emotion dysregulation as a transdiagnostic dimension with neurobiological underpinnings that transcend diagnostic boundaries, and adds evidence to neural variability being a relevant proxy of neural efficiency." @default.
• W3206997673 created "2021-10-25" @default.
• W3206997673 creator A5003535842 @default.
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• W3206997673 date "2021-10-21" @default.
• W3206997673 modified "2023-10-18" @default.
• W3206997673 title "Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation" @default.
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• W3206997673 doi "https://doi.org/10.1038/s41398-021-01666-3" @default.
• W3206997673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8530999" @default.
• W3206997673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34675186" @default.
• W3206997673 hasPublicationYear "2021" @default.

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