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- W3207019778 abstract "Immunotherapy with PD-1/PD-L1 antibody is now the standard of care for the treatment of metastatic non-small cell lung cancer (NSCLC) but many tumors develop PD-1/PD-L1 resistance. We hypothesize based on existing preclinical and clinical data that combining a T-cell agonist such as varlilumab (anti-CD27 antibody) with checkpoint inhibition may be synergistic and this synergy may be potentiated further by using targeted radiation. Targeted radiation improves antigen presentation and immune infiltration and this combination may help overcoming resistance to PD-1/PD-L1 therapies for the treatment of NSCLC." @default.
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- W3207019778 date "2021-10-01" @default.
- W3207019778 modified "2023-10-16" @default.
- W3207019778 title "FP03.02 A Phase I Trial of Atezolizumab and Varlilumab in Combination With Radiation in Patients with Metastatic Non-Small Cell Lung Cancer" @default.
- W3207019778 doi "https://doi.org/10.1016/j.jtho.2021.08.212" @default.
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