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- W3207024762 abstract "Acute pancreatitis (AP) is a common disorder with significant hospital admission and mortality. Due to the unclarified pathological mechanism, there is still no effective and specific treatment for AP. Recently, autophagy has been found to be closely related with occurrence and development of AP, which is crucial in determining its severity and outcomes. Emerging evidence indicates that autophagy can be regulated and influenced by microRNAs and organelles, including mitochondria, endoplasmic reticulum and lysosome, through various ways in AP. Of note, the complex interplays and close relationships among autophagy, microRNA and organelles in AP are vital for figuring out pathogenesis but not clear yet. Thus, this review summarizes the role of autophagy in the pathological mechanism of AP, especially the relationship between impaired autophagy and organelles, and discusses the regulatory mechanism of microRNA on autophagy, which could offer new insights into understanding the pathogenesis of AP and developing new potential therapeutic targets against AP." @default.
- W3207024762 created "2021-10-25" @default.
- W3207024762 creator A5004292559 @default.
- W3207024762 creator A5021355100 @default.
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- W3207024762 creator A5065912071 @default.
- W3207024762 creator A5083990646 @default.
- W3207024762 date "2021-02-05" @default.
- W3207024762 modified "2023-10-14" @default.
- W3207024762 title "Autophagy in Acute Pancreatitis: Organelle Interaction and microRNA Regulation" @default.
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