Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207066708> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W3207066708 endingPage "88" @default.
- W3207066708 startingPage "78" @default.
- W3207066708 abstract "Balamuthia mandrillaris is an opportunistic, free-living ameba that is pathogenic to humans. It has a worldwide distribution but is mainly detected in warmer regions. Balamuthia infections are rare but have been reported in both immunocompetent and immunocompromised individuals of all ages. B. mandrillaris can enter through wounds on the skin or the nose and cause cutaneous lesions and the usually fatal Balamuthia amebic encephalitis (BAE). Infection usually spreads from the lungs or through nerve fibers, and attacks the central nervous system, forming granulomatous lesions and necrosis in the brain. Balamuthia infection is usually chronic, and patients initially present with nonspecific symptoms, including headache, nausea, myalgia, and low-grade fever. As the disease progresses, the patient becomes paralyzed and comatose, often leading to death. Lack of knowledge of predisposing factors, specific treatment, and standardized detection tools have resulted in a nearly cent percent fatality rate. Although only about 200 cases have been reported worldwide since its characterization in the 1990s, the number of reported cases has increased over the years. BAE is an emerging disease and a major health concern. Few patients have survived Balamuthia infections with antimicrobial treatment that has largely been empirical. Early diagnosis is the key and requires familiarity with the disease and a high degree of suspicion on the part of the diagnostician. There are currently no specific treatment and prevention recommendations. This review highlights our current understanding of B. mandrillaris in terms of its pathogenicity, genomics, and novel diagnostic and therapeutic approaches against BAE infections." @default.
- W3207066708 created "2021-10-25" @default.
- W3207066708 creator A5073325183 @default.
- W3207066708 creator A5089860569 @default.
- W3207066708 date "2021-11-13" @default.
- W3207066708 modified "2023-09-29" @default.
- W3207066708 title "Balamuthia mandrillaris: An opportunistic, free-living ameba - An updated review." @default.
- W3207066708 doi "https://doi.org/10.4103/tp.tp_36_21" @default.
- W3207066708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8579774" @default.
- W3207066708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34765527" @default.
- W3207066708 hasPublicationYear "2021" @default.
- W3207066708 type Work @default.
- W3207066708 sameAs 3207066708 @default.
- W3207066708 citedByCount "7" @default.
- W3207066708 countsByYear W32070667082022 @default.
- W3207066708 countsByYear W32070667082023 @default.
- W3207066708 crossrefType "journal-article" @default.
- W3207066708 hasAuthorship W3207066708A5073325183 @default.
- W3207066708 hasAuthorship W3207066708A5089860569 @default.
- W3207066708 hasConcept C107130276 @default.
- W3207066708 hasConcept C142724271 @default.
- W3207066708 hasConcept C16005928 @default.
- W3207066708 hasConcept C177713679 @default.
- W3207066708 hasConcept C187316915 @default.
- W3207066708 hasConcept C2779134260 @default.
- W3207066708 hasConcept C71924100 @default.
- W3207066708 hasConceptScore W3207066708C107130276 @default.
- W3207066708 hasConceptScore W3207066708C142724271 @default.
- W3207066708 hasConceptScore W3207066708C16005928 @default.
- W3207066708 hasConceptScore W3207066708C177713679 @default.
- W3207066708 hasConceptScore W3207066708C187316915 @default.
- W3207066708 hasConceptScore W3207066708C2779134260 @default.
- W3207066708 hasConceptScore W3207066708C71924100 @default.
- W3207066708 hasIssue "2" @default.
- W3207066708 hasLocation W32070667081 @default.
- W3207066708 hasOpenAccess W3207066708 @default.
- W3207066708 hasPrimaryLocation W32070667081 @default.
- W3207066708 hasRelatedWork W10528703 @default.
- W3207066708 hasRelatedWork W12947590 @default.
- W3207066708 hasRelatedWork W13024550 @default.
- W3207066708 hasRelatedWork W13352886 @default.
- W3207066708 hasRelatedWork W3171258 @default.
- W3207066708 hasRelatedWork W4393958 @default.
- W3207066708 hasRelatedWork W5665152 @default.
- W3207066708 hasRelatedWork W7847298 @default.
- W3207066708 hasRelatedWork W8121574 @default.
- W3207066708 hasRelatedWork W3973958 @default.
- W3207066708 hasVolume "11" @default.
- W3207066708 isParatext "false" @default.
- W3207066708 isRetracted "false" @default.
- W3207066708 magId "3207066708" @default.
- W3207066708 workType "article" @default.