FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207067248> ?p ?o ?g. }

• W3207067248 endingPage "e0258789" @default.
• W3207067248 startingPage "e0258789" @default.
• W3207067248 abstract "Background Several meta-analyses of the relationship between endothelial nitric oxide synthase (eNOS) T-786C gene polymorphism and chronic kidney disease (CKD) have been published. However, the results of these studies were inconsistent, and it is undetermined whether sample sizes are sufficient to reach a definite conclusion. Objective To elucidate the relationship between T-786C and CKD by combining previous studies with our case-control sample and incorporate trial sequential analysis (TSA) to verify whether the sample size is adequate to draw a definite conclusion. Methods PubMed and Embase databases were searched for relevant articles on eNOS T-786C and CKD before February 28, 2021. TSA was also incorporated to ascertain a conclusion. A total of 558 hemodialysis cases in the case-control study was recruited from nine dialysis centers in the northern area of Taiwan in 2020. Additionally, 640 healthy subjects of the control group, with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m 2 , were selected from participants of the annual elderly health examination program at the Tri-Service General Hospital. The functional analysis was based on eQTL data from GTExPortal. Results After screening with eligibility criteria, 15 papers were included and eventually combined in a meta-analysis. The result of the TSA showed that the sample size for Caucasians was adequate to ascertain the correlation between eNOS T-786C and CKD but was insufficient for Asians. Therefore, we added our case-control samples (n = 1198), though not associated with CKD (odds ratio [OR] = 1.01, 95% confidence interval [CI] = 0.69–1.46), into a meta-analysis, which supported that eNOS T-786C was significantly associated with CKD in Asians (OR = 1.39, 95% CI = 1.04–1.85) by using an adequate cumulative sample size (n = 4572) analyzed by TSA. Data of eQTL from GTEx showed that T-786C with the C minor allele exhibited relatively lower eNOS mRNA expression in whole blood, indicating the hazardous role of eNOS T-786C in CKD. Conclusions eNOS T-786C genetic polymorphism was of conclusive significance in the association with CKD among Asians in our meta-analysis. Our case-control samples play a decisive role in changing conclusions from indefinite to definite." @default.
• W3207067248 created "2021-10-25" @default.
• W3207067248 creator A5016270100 @default.
• W3207067248 creator A5028797446 @default.
• W3207067248 creator A5030856558 @default.
• W3207067248 creator A5038205709 @default.
• W3207067248 creator A5043598789 @default.
• W3207067248 creator A5061500739 @default.
• W3207067248 creator A5062159166 @default.
• W3207067248 creator A5075292315 @default.
• W3207067248 creator A5076903478 @default.
• W3207067248 date "2021-10-18" @default.
• W3207067248 modified "2023-10-18" @default.
• W3207067248 title "Association between nitric oxide synthase T-786C genetic polymorphism and chronic kidney disease: Meta-analysis incorporating trial sequential analysis" @default.
• W3207067248 cites W1552789483 @default.
• W3207067248 cites W1922859388 @default.
• W3207067248 cites W1968858328 @default.
• W3207067248 cites W1978183768 @default.
• W3207067248 cites W1979065105 @default.
• W3207067248 cites W1997023449 @default.
• W3207067248 cites W2001252075 @default.
• W3207067248 cites W2007737411 @default.
• W3207067248 cites W2018838463 @default.
• W3207067248 cites W2030103617 @default.
• W3207067248 cites W2033077454 @default.
• W3207067248 cites W2037071450 @default.
• W3207067248 cites W2049852456 @default.
• W3207067248 cites W2055513929 @default.
• W3207067248 cites W2070650235 @default.
• W3207067248 cites W2073977224 @default.
• W3207067248 cites W2080570847 @default.
• W3207067248 cites W2088195972 @default.
• W3207067248 cites W2101447446 @default.
• W3207067248 cites W2101927474 @default.
• W3207067248 cites W2102101813 @default.
• W3207067248 cites W2102945991 @default.
• W3207067248 cites W2108462343 @default.
• W3207067248 cites W2119605658 @default.
• W3207067248 cites W2123516460 @default.
• W3207067248 cites W2129433078 @default.
• W3207067248 cites W2139168999 @default.
• W3207067248 cites W2144419159 @default.
• W3207067248 cites W2147534219 @default.
• W3207067248 cites W2165019590 @default.
• W3207067248 cites W2170215250 @default.
• W3207067248 cites W2302635387 @default.
• W3207067248 cites W2418544085 @default.
• W3207067248 cites W2470481127 @default.
• W3207067248 cites W2500671045 @default.
• W3207067248 cites W2620913062 @default.
• W3207067248 cites W2778307416 @default.
• W3207067248 cites W2807285359 @default.
• W3207067248 cites W2944634763 @default.
• W3207067248 cites W2972470369 @default.
• W3207067248 cites W2979208099 @default.
• W3207067248 cites W2995495466 @default.
• W3207067248 cites W3004491707 @default.
• W3207067248 cites W3007827011 @default.
• W3207067248 cites W3023146098 @default.
• W3207067248 cites W3038944827 @default.
• W3207067248 cites W3041287992 @default.
• W3207067248 cites W3042393018 @default.
• W3207067248 cites W3044339706 @default.
• W3207067248 cites W4255342727 @default.
• W3207067248 cites W4294215472 @default.
• W3207067248 doi "https://doi.org/10.1371/journal.pone.0258789" @default.
• W3207067248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8523046" @default.
• W3207067248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34662360" @default.
• W3207067248 hasPublicationYear "2021" @default.
• W3207067248 type Work @default.
• W3207067248 sameAs 3207067248 @default.
• W3207067248 citedByCount "0" @default.
• W3207067248 crossrefType "journal-article" @default.
• W3207067248 hasAuthorship W3207067248A5016270100 @default.
• W3207067248 hasAuthorship W3207067248A5028797446 @default.
• W3207067248 hasAuthorship W3207067248A5030856558 @default.
• W3207067248 hasAuthorship W3207067248A5038205709 @default.
• W3207067248 hasAuthorship W3207067248A5043598789 @default.
• W3207067248 hasAuthorship W3207067248A5061500739 @default.
• W3207067248 hasAuthorship W3207067248A5062159166 @default.
• W3207067248 hasAuthorship W3207067248A5075292315 @default.
• W3207067248 hasAuthorship W3207067248A5076903478 @default.
• W3207067248 hasBestOaLocation W32070672481 @default.
• W3207067248 hasConcept C105795698 @default.
• W3207067248 hasConcept C126322002 @default.
• W3207067248 hasConcept C129848803 @default.
• W3207067248 hasConcept C156957248 @default.
• W3207067248 hasConcept C159641895 @default.
• W3207067248 hasConcept C168563851 @default.
• W3207067248 hasConcept C187960798 @default.
• W3207067248 hasConcept C2777622882 @default.
• W3207067248 hasConcept C2778326061 @default.
• W3207067248 hasConcept C2778653478 @default.
• W3207067248 hasConcept C2779978075 @default.
• W3207067248 hasConcept C33923547 @default.
• W3207067248 hasConcept C44249647 @default.
• W3207067248 hasConcept C519581460 @default.
• W3207067248 hasConcept C71924100 @default.

• next