FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207080005> ?p ?o ?g. }

• W3207080005 endingPage "134" @default.
• W3207080005 startingPage "126" @default.
• W3207080005 abstract "Radiation-induced myelopathy, an irreversible complication occurring after a long symptom-free latency time, is preceded by a fixed sequence of magnetic resonance- (MR-) visible morphological alterations. Vascular degradation is assumed the main reason for radiation-induced myelopathy. We used dynamic contrast-enhanced (DCE-) MRI to identify different vascular changes after photon and carbon ion irradiation, which precede or coincide with morphological changes.The cervical spinal cord of rats was irradiated with iso-effective photon or carbon (12C-)ion doses. Afterwards, animals underwent frequent DCE-MR imaging until they developed symptomatic radiation-induced myelopathy (paresis II). Measurements were performed at certain time points: 1 month, 2 months, 3 months, 4 months, and 6 months after irradiation, and when animals showed morphological (such as edema/syrinx/contrast agent (CA) accumulation) or neurological alterations (such as, paresis I, and paresis II). DCE-MRI data was analyzed using the extended Toft's model.Fit quality improved with gradual disintegration of the blood spinal cord barrier (BSCB) towards paresis II. Vascular permeability increased three months after photon irradiation, and rapidly escalated after animals showed MR-visible morphological changes until paresis II. After 12C-ion irradiation, vascular permeability increased when animals showed morphological alterations and increased further until animals had paresis II. The volume transfer constant and the plasma volume showed no significant changes.Only after photon irradiation, DCE-MRI provides a temporal advantage in detecting early physiological signs in radiation-induced myelopathy compared to morphological MRI. As a generally lower level of vascular permeability after 12C-ions led to an earlier development of paresis as compared to photons, we conclude that other mechanisms dominate the development of paresis II." @default.
• W3207080005 created "2021-10-25" @default.
• W3207080005 creator A5011687029 @default.
• W3207080005 creator A5014498443 @default.
• W3207080005 creator A5015061264 @default.
• W3207080005 creator A5021544846 @default.
• W3207080005 creator A5021999208 @default.
• W3207080005 creator A5060012383 @default.
• W3207080005 creator A5072906611 @default.
• W3207080005 creator A5079460128 @default.
• W3207080005 creator A5089692791 @default.
• W3207080005 date "2021-12-01" @default.
• W3207080005 modified "2023-09-23" @default.
• W3207080005 title "DCE-MRI detected vascular permeability changes in the rat spinal cord do not explain shorter latency times for paresis after carbon ions relative to photons" @default.
• W3207080005 cites W1521262132 @default.
• W3207080005 cites W1535417994 @default.
• W3207080005 cites W1967455939 @default.
• W3207080005 cites W1985641367 @default.
• W3207080005 cites W1986248470 @default.
• W3207080005 cites W1991938051 @default.
• W3207080005 cites W1992997522 @default.
• W3207080005 cites W1995317347 @default.
• W3207080005 cites W2015475838 @default.
• W3207080005 cites W2025236977 @default.
• W3207080005 cites W2026859468 @default.
• W3207080005 cites W2039604691 @default.
• W3207080005 cites W2042098439 @default.
• W3207080005 cites W2044269571 @default.
• W3207080005 cites W2044640315 @default.
• W3207080005 cites W2047600082 @default.
• W3207080005 cites W2047752735 @default.
• W3207080005 cites W2054479861 @default.
• W3207080005 cites W2056319562 @default.
• W3207080005 cites W2063480100 @default.
• W3207080005 cites W2063872981 @default.
• W3207080005 cites W2068663150 @default.
• W3207080005 cites W2069308124 @default.
• W3207080005 cites W2070772485 @default.
• W3207080005 cites W2078858327 @default.
• W3207080005 cites W2091633428 @default.
• W3207080005 cites W2092459498 @default.
• W3207080005 cites W2104421165 @default.
• W3207080005 cites W2108955260 @default.
• W3207080005 cites W2124871474 @default.
• W3207080005 cites W2129688871 @default.
• W3207080005 cites W2135999437 @default.
• W3207080005 cites W2164008925 @default.
• W3207080005 cites W2170619710 @default.
• W3207080005 cites W2174482320 @default.
• W3207080005 cites W2230859920 @default.
• W3207080005 cites W2403175608 @default.
• W3207080005 cites W2510208083 @default.
• W3207080005 cites W2604555220 @default.
• W3207080005 cites W2752844851 @default.
• W3207080005 cites W2783629634 @default.
• W3207080005 cites W2884469308 @default.
• W3207080005 cites W2885109878 @default.
• W3207080005 cites W2897747977 @default.
• W3207080005 cites W2966149428 @default.
• W3207080005 cites W2984809842 @default.
• W3207080005 cites W3042700282 @default.
• W3207080005 cites W3044125576 @default.
• W3207080005 cites W3113707889 @default.
• W3207080005 doi "https://doi.org/10.1016/j.radonc.2021.09.035" @default.
• W3207080005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34634380" @default.
• W3207080005 hasPublicationYear "2021" @default.
• W3207080005 type Work @default.
• W3207080005 sameAs 3207080005 @default.
• W3207080005 citedByCount "2" @default.
• W3207080005 countsByYear W32070800052022 @default.
• W3207080005 countsByYear W32070800052023 @default.
• W3207080005 crossrefType "journal-article" @default.
• W3207080005 hasAuthorship W3207080005A5011687029 @default.
• W3207080005 hasAuthorship W3207080005A5014498443 @default.
• W3207080005 hasAuthorship W3207080005A5015061264 @default.
• W3207080005 hasAuthorship W3207080005A5021544846 @default.
• W3207080005 hasAuthorship W3207080005A5021999208 @default.
• W3207080005 hasAuthorship W3207080005A5060012383 @default.
• W3207080005 hasAuthorship W3207080005A5072906611 @default.
• W3207080005 hasAuthorship W3207080005A5079460128 @default.
• W3207080005 hasAuthorship W3207080005A5089692791 @default.
• W3207080005 hasConcept C111337013 @default.
• W3207080005 hasConcept C118552586 @default.
• W3207080005 hasConcept C121332964 @default.
• W3207080005 hasConcept C126838900 @default.
• W3207080005 hasConcept C141071460 @default.
• W3207080005 hasConcept C142724271 @default.
• W3207080005 hasConcept C143409427 @default.
• W3207080005 hasConcept C185544564 @default.
• W3207080005 hasConcept C185592680 @default.
• W3207080005 hasConcept C2777604421 @default.
• W3207080005 hasConcept C2778879792 @default.
• W3207080005 hasConcept C2779632786 @default.
• W3207080005 hasConcept C2780775167 @default.
• W3207080005 hasConcept C2989005 @default.
• W3207080005 hasConcept C71924100 @default.
• W3207080005 hasConceptScore W3207080005C111337013 @default.
• W3207080005 hasConceptScore W3207080005C118552586 @default.

• next