FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207091808> ?p ?o ?g. }

• W3207091808 endingPage "13" @default.
• W3207091808 startingPage "1" @default.
• W3207091808 abstract "The aim of this study was at investigating the association between major depressive disorder (MDD) and periodontitis based on crosstalk genes and neuropeptides.Datasets for periodontitis (GSE10334, GSE16134, and GSE23586) and MDD (GSE38206 and GSE39653) were downloaded from GEO. Following batch correction, a differential expression analysis was applied (MDD: ∣log2FC | >0 and periodontitis ∣log2FC | ≥0.5, p < 0.05). The neuropeptide data were downloaded from NeuroPep and NeuroPedia. Intersected genes were potential crosstalk genes. The correlation between neuropeptides and crosstalk genes in MDD and periodontitis was analyzed with Pearson correlation coefficient. Subsequently, regression analysis was performed to calculate the differentially regulated link. Cytoscape was used to map the pathways of crosstalk genes and neuropeptides and to construct the protein-protein interaction network. Lasso regression was applied to screen neuropeptides, whereby boxplots were created, and receiver operating curve (ROC) analysis was conducted.The MDD dataset contained 30 case and 33 control samples, and the periodontitis dataset contained 430 case and 139 control samples. 35 crosstalk genes were obtained. A total of 102 neuropeptides were extracted from the database, which were not differentially expressed in MDD and periodontitis and had no intersection with crosstalk genes. Through lasso regression, 9 neuropeptides in MDD and 43 neuropeptides in periodontitis were obtained. Four intersected neuropeptide genes were obtained, i.e., ADM, IGF2, PDYN, and RETN. The results of ROC analysis showed that IGF2 was highly predictive in MDD and periodontitis. ADM was better than the other three genes in predicting MDD disease. A total of 13 crosstalk genes were differentially coexpressed with four neuropeptides, whereby FOSB was highly expressed in MDD and periodontitis.The neuropeptide genes ADM, IGF2, PDYN, and RETN were intersected between periodontitis and MDD, and FOSB was a crosstalk gene related to these neuropeptides on the transcriptomic level. These results are a basis for future research in the field, needing further validation." @default.
• W3207091808 created "2021-10-25" @default.
• W3207091808 creator A5001228999 @default.
• W3207091808 creator A5003158091 @default.
• W3207091808 creator A5010907733 @default.
• W3207091808 creator A5041150434 @default.
• W3207091808 creator A5054051854 @default.
• W3207091808 creator A5083420886 @default.
• W3207091808 date "2021-10-21" @default.
• W3207091808 modified "2023-10-18" @default.
• W3207091808 title "Neuropeptides as the Shared Genetic Crosstalks Linking Periodontitis and Major Depression Disorder" @default.
• W3207091808 cites W1967029537 @default.
• W3207091808 cites W1973975463 @default.
• W3207091808 cites W1976143235 @default.
• W3207091808 cites W1984227898 @default.
• W3207091808 cites W1997728372 @default.
• W3207091808 cites W2020968501 @default.
• W3207091808 cites W2022156965 @default.
• W3207091808 cites W2028072333 @default.
• W3207091808 cites W2042045791 @default.
• W3207091808 cites W2042990492 @default.
• W3207091808 cites W2049704911 @default.
• W3207091808 cites W2074040364 @default.
• W3207091808 cites W2076363539 @default.
• W3207091808 cites W2089795542 @default.
• W3207091808 cites W2090344561 @default.
• W3207091808 cites W2093663596 @default.
• W3207091808 cites W2096799128 @default.
• W3207091808 cites W2096856326 @default.
• W3207091808 cites W2100391099 @default.
• W3207091808 cites W2106515001 @default.
• W3207091808 cites W2131810039 @default.
• W3207091808 cites W2138293945 @default.
• W3207091808 cites W2147331510 @default.
• W3207091808 cites W2244936729 @default.
• W3207091808 cites W2331522075 @default.
• W3207091808 cites W2494649623 @default.
• W3207091808 cites W2518604970 @default.
• W3207091808 cites W2768488673 @default.
• W3207091808 cites W2802167103 @default.
• W3207091808 cites W2884516035 @default.
• W3207091808 cites W2890786947 @default.
• W3207091808 cites W2903190519 @default.
• W3207091808 cites W2940380740 @default.
• W3207091808 cites W2965092027 @default.
• W3207091808 cites W2972398186 @default.
• W3207091808 cites W2990461417 @default.
• W3207091808 cites W3036583252 @default.
• W3207091808 cites W3093041711 @default.
• W3207091808 cites W3093824759 @default.
• W3207091808 cites W3121058598 @default.
• W3207091808 cites W3127869646 @default.
• W3207091808 cites W3146619815 @default.
• W3207091808 cites W4211223324 @default.
• W3207091808 doi "https://doi.org/10.1155/2021/3683189" @default.
• W3207091808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8553477" @default.
• W3207091808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34721734" @default.
• W3207091808 hasPublicationYear "2021" @default.
• W3207091808 type Work @default.
• W3207091808 sameAs 3207091808 @default.
• W3207091808 citedByCount "5" @default.
• W3207091808 countsByYear W32070918082022 @default.
• W3207091808 countsByYear W32070918082023 @default.
• W3207091808 crossrefType "journal-article" @default.
• W3207091808 hasAuthorship W3207091808A5001228999 @default.
• W3207091808 hasAuthorship W3207091808A5003158091 @default.
• W3207091808 hasAuthorship W3207091808A5010907733 @default.
• W3207091808 hasAuthorship W3207091808A5041150434 @default.
• W3207091808 hasAuthorship W3207091808A5054051854 @default.
• W3207091808 hasAuthorship W3207091808A5083420886 @default.
• W3207091808 hasBestOaLocation W32070918081 @default.
• W3207091808 hasConcept C104317684 @default.
• W3207091808 hasConcept C118303440 @default.
• W3207091808 hasConcept C120665830 @default.
• W3207091808 hasConcept C121332964 @default.
• W3207091808 hasConcept C126322002 @default.
• W3207091808 hasConcept C169822122 @default.
• W3207091808 hasConcept C170493617 @default.
• W3207091808 hasConcept C2780385504 @default.
• W3207091808 hasConcept C54355233 @default.
• W3207091808 hasConcept C58471807 @default.
• W3207091808 hasConcept C60644358 @default.
• W3207091808 hasConcept C70721500 @default.
• W3207091808 hasConcept C71924100 @default.
• W3207091808 hasConcept C86803240 @default.
• W3207091808 hasConceptScore W3207091808C104317684 @default.
• W3207091808 hasConceptScore W3207091808C118303440 @default.
• W3207091808 hasConceptScore W3207091808C120665830 @default.
• W3207091808 hasConceptScore W3207091808C121332964 @default.
• W3207091808 hasConceptScore W3207091808C126322002 @default.
• W3207091808 hasConceptScore W3207091808C169822122 @default.
• W3207091808 hasConceptScore W3207091808C170493617 @default.
• W3207091808 hasConceptScore W3207091808C2780385504 @default.
• W3207091808 hasConceptScore W3207091808C54355233 @default.
• W3207091808 hasConceptScore W3207091808C58471807 @default.
• W3207091808 hasConceptScore W3207091808C60644358 @default.
• W3207091808 hasConceptScore W3207091808C70721500 @default.
• W3207091808 hasConceptScore W3207091808C71924100 @default.

• next