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• W3207124927 endingPage "1439" @default.
• W3207124927 startingPage "1425" @default.
• W3207124927 abstract "Gastrointestinal (GI) cancers, including malignancies in the gastrointestinal tract and accessory organs of digestion, represent the leading cause of death worldwide due to the poor prognosis of most GI cancers. An investigation into the potential molecular targets of prediction, diagnosis, prognosis, and therapy in GI cancers is urgently required. Proliferating cell nuclear antigen (PCNA) clamp associated factor (PCLAF), which plays an essential role in cell proliferation, apoptosis, and cell cycle regulation by binding to PCNA, is a potential molecular target of GI cancers as it contributes to a series of malignant properties, including tumorigenesis, epithelial-mesenchymal transition, migration, and invasion. Furthermore, PCLAF is an underlying plasma prediction target in colorectal cancer and liver cancer. In addition to GI cancers, PCLAF is also involved in other types of cancers and autoimmune diseases. Several pivotal pathways, including the Rb/E2F pathway, NF-κB pathway, and p53-p21 cascade, are implicated in PCLAF-mediated diseases. PCLAF also contributes to some diseases through dysregulation of the p53 pathway, WNT signal pathway, MEK/ERK pathway, and PI3K/AKT/mTOR signal cascade. This review mainly describes in detail the role of PCLAF in physiological status and GI cancers. The signaling pathways involved in PCLAF are also summarized. Suppression of the interaction of PCLAF/PCNA or the expression of PCLAF might be potential biological therapeutic strategies for GI cancers." @default.
• W3207124927 created "2021-10-25" @default.
• W3207124927 creator A5001665699 @default.
• W3207124927 creator A5017296972 @default.
• W3207124927 creator A5035779878 @default.
• W3207124927 date "2021-10-15" @default.
• W3207124927 modified "2023-10-01" @default.
• W3207124927 title "Proliferating cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors" @default.
• W3207124927 cites W1492693073 @default.
• W3207124927 cites W1678175179 @default.
• W3207124927 cites W1973558438 @default.
• W3207124927 cites W1987584325 @default.
• W3207124927 cites W1996875487 @default.
• W3207124927 cites W1997360704 @default.
• W3207124927 cites W2002630715 @default.
• W3207124927 cites W2011826559 @default.
• W3207124927 cites W2016358101 @default.
• W3207124927 cites W2019037458 @default.
• W3207124927 cites W2024204178 @default.
• W3207124927 cites W2030311708 @default.
• W3207124927 cites W2036785858 @default.
• W3207124927 cites W2038599420 @default.
• W3207124927 cites W2039219266 @default.
• W3207124927 cites W2040498703 @default.
• W3207124927 cites W2046359103 @default.
• W3207124927 cites W2047198790 @default.
• W3207124927 cites W2054780785 @default.
• W3207124927 cites W2055615682 @default.
• W3207124927 cites W2058169032 @default.
• W3207124927 cites W2066925975 @default.
• W3207124927 cites W2069970995 @default.
• W3207124927 cites W2070845123 @default.
• W3207124927 cites W2074178149 @default.
• W3207124927 cites W2074438676 @default.
• W3207124927 cites W2082598141 @default.
• W3207124927 cites W2088321565 @default.
• W3207124927 cites W2090255529 @default.
• W3207124927 cites W2091747793 @default.
• W3207124927 cites W2092219219 @default.
• W3207124927 cites W2099526120 @default.
• W3207124927 cites W2100905005 @default.
• W3207124927 cites W2106299774 @default.
• W3207124927 cites W2114302755 @default.
• W3207124927 cites W2128378918 @default.
• W3207124927 cites W2129242642 @default.
• W3207124927 cites W2134887638 @default.
• W3207124927 cites W2150509292 @default.
• W3207124927 cites W2153679407 @default.
• W3207124927 cites W2154329369 @default.
• W3207124927 cites W2213630852 @default.
• W3207124927 cites W2247983356 @default.
• W3207124927 cites W2261546926 @default.
• W3207124927 cites W2291124025 @default.
• W3207124927 cites W2296697784 @default.
• W3207124927 cites W2336588424 @default.
• W3207124927 cites W2344919930 @default.
• W3207124927 cites W2416998552 @default.
• W3207124927 cites W2422294114 @default.
• W3207124927 cites W2512945417 @default.
• W3207124927 cites W2524649932 @default.
• W3207124927 cites W2544079919 @default.
• W3207124927 cites W2597862563 @default.
• W3207124927 cites W2606325767 @default.
• W3207124927 cites W2765581398 @default.
• W3207124927 cites W2765636880 @default.
• W3207124927 cites W2772558468 @default.
• W3207124927 cites W2808699914 @default.
• W3207124927 cites W2888197260 @default.
• W3207124927 cites W2889646458 @default.
• W3207124927 cites W2892327475 @default.
• W3207124927 cites W2898432897 @default.
• W3207124927 cites W2900250217 @default.
• W3207124927 cites W2936325197 @default.
• W3207124927 cites W2951411546 @default.
• W3207124927 cites W2971735282 @default.
• W3207124927 cites W2992369313 @default.
• W3207124927 cites W2995755896 @default.
• W3207124927 cites W3006080438 @default.
• W3207124927 cites W3008049779 @default.
• W3207124927 cites W3082145475 @default.
• W3207124927 cites W3083407644 @default.
• W3207124927 cites W3088674025 @default.
• W3207124927 cites W3090920141 @default.
• W3207124927 cites W3110253998 @default.
• W3207124927 cites W3112713482 @default.
• W3207124927 cites W3117280978 @default.
• W3207124927 cites W3119005666 @default.
• W3207124927 cites W3126716989 @default.
• W3207124927 cites W3127893047 @default.
• W3207124927 cites W3129551551 @default.
• W3207124927 cites W3130722519 @default.
• W3207124927 cites W3152367649 @default.
• W3207124927 cites W3163803570 @default.
• W3207124927 doi "https://doi.org/10.4251/wjgo.v13.i10.1425" @default.
• W3207124927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8529917" @default.
• W3207124927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34721775" @default.
• W3207124927 hasPublicationYear "2021" @default.
• W3207124927 type Work @default.

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