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- W3207145891 abstract "<h3>Background</h3> A transient, self-limiting aplastic crisis is a rare manifestation of parvovirus (PV) B19 infection, usually seen in patients with underlying haemolytic anaemias. The virus has a predilection for infecting the erythroid progenitor cells of the bone marrow resulting in their lysis and red cell aplasia, although white cell and platelet counts may also decline. We herein report aplastic crisis induced by PV B19 infection unmasking hereditary spherocytosis in a boy. <h3>Case Presentation</h3> A 11-year-old boy presented with high-grade fever, headache, drowsiness, sore throat, and a rash. On admission he was conscious, but sleepy, drooling, with pale skin and conjunctivae. Physical examination revealed macular, somewhere petechial rash involving the neck and extremities, tachycardia, systolic murmur and hepatosplenomegaly. Complete blood count revealed RBC of 2.34 x10e12/L, with haemoglobin concentration of 64 g/L and reticulocytopenia, WBC 1.3×10e9/L, and platelet count 75×10e9/L. Spherocytosis was present on the peripheral blood smear. Bone marrow aspirate showed suppressed erythropoiesis. The PV B19 infection was diagnosed by polymerase chain reaction (292 000 000 DNA copies/ml of blood) and positive serology for specific anti-PV B19 IgM. Osmotic fragility testing showed increased fragility of erythrocytes, which was consistent with the diagnosis of hereditary spherocytosis. The boy was treated by blood and platelet transfusions and supportive care, and was discharged after 9 days of hospital care with improved blood count. <h3>Conclusions</h3> PV B19 induced aplastic crisis can be the first manifestation of hereditary spherocytosis. PV B19 infection must be considered in the differential diagnosis in patients with acquired aplastic anaemia." @default.
- W3207145891 created "2021-10-25" @default.
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- W3207145891 date "2021-10-01" @default.
- W3207145891 modified "2023-09-25" @default.
- W3207145891 title "325 Aplastic crisis induced by human parvovirus B19 as an initial presentation of hereditary spherocytosis in a child – a case report" @default.
- W3207145891 doi "https://doi.org/10.1136/archdischild-2021-europaediatrics.325" @default.
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