Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207146695> ?p ?o ?g. }
- W3207146695 endingPage "2103320" @default.
- W3207146695 startingPage "2103320" @default.
- W3207146695 abstract "While decades of research have enriched the knowledge of how to grow cells into mature tissues, little is yet known about the next phase: fusing of these engineered tissues into larger functional structures. The specific effect of multicellular interfaces on tissue fusion remains largely unexplored. Here, a facile 3D-bioassembly platform is introduced to primarily study fusion of cartilage-cartilage interfaces using spheroids formed from human mesenchymal stromal cells (hMSCs) and articular chondrocytes (hACs). 3D-bioassembly of two adjacent hMSCs spheroids displays coordinated migration and noteworthy matrix deposition while the interface between two hAC tissues lacks both cells and type-II collagen. Cocultures contribute to increased phenotypic stability in the fusion region while close initial contact between hMSCs and hACs (mixed) yields superior hyaline differentiation over more distant, indirect cocultures. This reduced ability of potent hMSCs to fuse with mature hAC tissue further underlines the major clinical challenge that is integration. Together, this data offer the first proof of an in vitro 3D-model to reliably study lateral fusion mechanisms between multicellular spheroids and mature cartilage tissues. Ultimately, this high-throughput 3D-bioassembly model provides a bridge between understanding cellular differentiation and tissue fusion and offers the potential to probe fundamental biological mechanisms that underpin organogenesis." @default.
- W3207146695 created "2021-10-25" @default.
- W3207146695 creator A5012738982 @default.
- W3207146695 creator A5015866577 @default.
- W3207146695 creator A5035925352 @default.
- W3207146695 creator A5060161379 @default.
- W3207146695 creator A5067659805 @default.
- W3207146695 creator A5069313277 @default.
- W3207146695 creator A5069821826 @default.
- W3207146695 creator A5088892854 @default.
- W3207146695 date "2021-10-10" @default.
- W3207146695 modified "2023-10-15" @default.
- W3207146695 title "Probing Multicellular Tissue Fusion of Cocultured Spheroids—A 3D‐Bioassembly Model" @default.
- W3207146695 cites W1544751778 @default.
- W3207146695 cites W1695009701 @default.
- W3207146695 cites W1887681690 @default.
- W3207146695 cites W1916928829 @default.
- W3207146695 cites W1968592374 @default.
- W3207146695 cites W1975890825 @default.
- W3207146695 cites W1988137436 @default.
- W3207146695 cites W1989739945 @default.
- W3207146695 cites W1992330985 @default.
- W3207146695 cites W1998250191 @default.
- W3207146695 cites W2000571117 @default.
- W3207146695 cites W2004290723 @default.
- W3207146695 cites W2005338062 @default.
- W3207146695 cites W2010334610 @default.
- W3207146695 cites W2011038175 @default.
- W3207146695 cites W2011087153 @default.
- W3207146695 cites W2014641370 @default.
- W3207146695 cites W2015050458 @default.
- W3207146695 cites W2016251547 @default.
- W3207146695 cites W2016332660 @default.
- W3207146695 cites W2018712244 @default.
- W3207146695 cites W2026101620 @default.
- W3207146695 cites W2026201824 @default.
- W3207146695 cites W2033858947 @default.
- W3207146695 cites W2036839600 @default.
- W3207146695 cites W2040155058 @default.
- W3207146695 cites W2042471750 @default.
- W3207146695 cites W2046855216 @default.
- W3207146695 cites W2059403602 @default.
- W3207146695 cites W2062549368 @default.
- W3207146695 cites W2066378061 @default.
- W3207146695 cites W2068246227 @default.
- W3207146695 cites W2078264122 @default.
- W3207146695 cites W2082273415 @default.
- W3207146695 cites W2084625366 @default.
- W3207146695 cites W2095242738 @default.
- W3207146695 cites W2098375711 @default.
- W3207146695 cites W2099748589 @default.
- W3207146695 cites W2111222524 @default.
- W3207146695 cites W2114241729 @default.
- W3207146695 cites W2116660289 @default.
- W3207146695 cites W2117832135 @default.
- W3207146695 cites W2118693030 @default.
- W3207146695 cites W2123633643 @default.
- W3207146695 cites W2124174283 @default.
- W3207146695 cites W2143979475 @default.
- W3207146695 cites W2145932168 @default.
- W3207146695 cites W2146147122 @default.
- W3207146695 cites W2153084247 @default.
- W3207146695 cites W2158493725 @default.
- W3207146695 cites W2159999899 @default.
- W3207146695 cites W2163412696 @default.
- W3207146695 cites W2165316896 @default.
- W3207146695 cites W2166021370 @default.
- W3207146695 cites W2166980716 @default.
- W3207146695 cites W2169596632 @default.
- W3207146695 cites W2177934058 @default.
- W3207146695 cites W2236789517 @default.
- W3207146695 cites W2260457320 @default.
- W3207146695 cites W2282235118 @default.
- W3207146695 cites W2293906275 @default.
- W3207146695 cites W2312256488 @default.
- W3207146695 cites W2343910187 @default.
- W3207146695 cites W2344794523 @default.
- W3207146695 cites W2399401173 @default.
- W3207146695 cites W2491221858 @default.
- W3207146695 cites W2504228461 @default.
- W3207146695 cites W2518273180 @default.
- W3207146695 cites W2531360666 @default.
- W3207146695 cites W2562922262 @default.
- W3207146695 cites W2588271989 @default.
- W3207146695 cites W2592871185 @default.
- W3207146695 cites W2604773103 @default.
- W3207146695 cites W2618729449 @default.
- W3207146695 cites W2622061524 @default.
- W3207146695 cites W2756194293 @default.
- W3207146695 cites W2765595220 @default.
- W3207146695 cites W2767094592 @default.
- W3207146695 cites W2771465293 @default.
- W3207146695 cites W2773232807 @default.
- W3207146695 cites W2775039059 @default.
- W3207146695 cites W2780538963 @default.
- W3207146695 cites W2800973555 @default.
- W3207146695 cites W2885484867 @default.
- W3207146695 cites W2887537465 @default.