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• W3207156777 abstract "Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed cardiovascular dysfunction in the offspring using an established rodent model of hypoxic pregnancy. Wistar rats were divided into normoxic (N) or hypoxic (H, 10% O2 ) pregnancy ± melatonin (M) treatment (5 μg·ml-1 .day-1 ) in the maternal drinking water. Hypoxia ± melatonin treatment was from day 15-20 of gestation (term is ca. 22 days). To control for possible effects of maternal hypoxia-induced reductions in maternal food intake, additional dams underwent pregnancy under normoxic conditions but were pair-fed (PF) to the daily amount consumed by hypoxic dams from day 15 of gestation. In one cohort of animals from each experimental group (N, NM, H, HM, PF, PFM), measurements were made at the end of gestation. In another, following delivery of the offspring, investigations were made at adulthood. In both fetal and adult offspring, fixed aorta and hearts were studied stereologically and frozen hearts were processed for molecular studies. In adult offspring, mesenteric vessels were isolated and vascular reactivity determined by in-vitro wire myography. Melatonin treatment during normoxic, hypoxic or pair-fed pregnancy elevated circulating plasma melatonin in the pregnant dam and fetus. Relative to normoxic pregnancy, hypoxic pregnancy increased fetal haematocrit, promoted asymmetric fetal growth restriction and resulted in accelerated postnatal catch-up growth. Whilst fetal offspring of hypoxic pregnancy showed aortic wall thickening, adult offspring of hypoxic pregnancy showed dilated cardiomyopathy. Similarly, whilst cardiac protein expression of eNOS was downregulated in the fetal heart, eNOS protein expression was elevated in the heart of adult offspring of hypoxic pregnancy. Adult offspring of hypoxic pregnancy further showed enhanced mesenteric vasoconstrictor reactivity to phenylephrine and the thromboxane mimetic U46619. The effects of hypoxic pregnancy on cardiovascular remodelling and function in the fetal and adult offspring were independent of hypoxia-induced reductions in maternal food intake. Conversely, the effects of hypoxic pregnancy on fetal and postanal growth were similar in pair-fed pregnancies. Whilst maternal treatment of normoxic or pair-fed pregnancies with melatonin on the offspring cardiovascular system was unremarkable, treatment of hypoxic pregnancies with melatonin in doses lower than those recommended for overcoming jet lag in humans enhanced fetal cardiac eNOS expression and prevented all alterations in cardiovascular structure and function in fetal and adult offspring. Therefore, the data support that melatonin is a potential therapeutic target for clinical intervention against developmental origins of cardiovascular dysfunction in pregnancy complicated by chronic fetal hypoxia." @default.
• W3207156777 created "2021-10-25" @default.
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• W3207156777 date "2021-10-22" @default.
• W3207156777 modified "2023-10-11" @default.
• W3207156777 title "Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy" @default.
• W3207156777 cites W135451564 @default.
• W3207156777 cites W1482915858 @default.
• W3207156777 cites W1485887944 @default.
• W3207156777 cites W1517681515 @default.
• W3207156777 cites W1530409697 @default.
• W3207156777 cites W1536484343 @default.
• W3207156777 cites W1546334556 @default.
• W3207156777 cites W1599340933 @default.
• W3207156777 cites W1875915783 @default.
• W3207156777 cites W1877005293 @default.
• W3207156777 cites W1925607687 @default.
• W3207156777 cites W1966726553 @default.
• W3207156777 cites W1967318727 @default.
• W3207156777 cites W1971627429 @default.
• W3207156777 cites W1972167719 @default.
• W3207156777 cites W1975605759 @default.
• W3207156777 cites W1978975856 @default.
• W3207156777 cites W1987150966 @default.
• W3207156777 cites W1993118127 @default.
• W3207156777 cites W1994890751 @default.
• W3207156777 cites W2000609745 @default.
• W3207156777 cites W2001688984 @default.
• W3207156777 cites W2003458674 @default.
• W3207156777 cites W2007049603 @default.
• W3207156777 cites W2013719945 @default.
• W3207156777 cites W2016184232 @default.
• W3207156777 cites W2016908715 @default.
• W3207156777 cites W2017080249 @default.
• W3207156777 cites W2018139315 @default.
• W3207156777 cites W2021201802 @default.
• W3207156777 cites W2021608780 @default.
• W3207156777 cites W2025517512 @default.
• W3207156777 cites W2028167086 @default.
• W3207156777 cites W2029577335 @default.
• W3207156777 cites W2032518276 @default.
• W3207156777 cites W2035038939 @default.
• W3207156777 cites W2044175751 @default.
• W3207156777 cites W2044185652 @default.
• W3207156777 cites W2046520869 @default.
• W3207156777 cites W2047479165 @default.
• W3207156777 cites W2053003164 @default.
• W3207156777 cites W2055614528 @default.
• W3207156777 cites W2066069844 @default.
• W3207156777 cites W2075476701 @default.
• W3207156777 cites W2090002569 @default.
• W3207156777 cites W2090559563 @default.
• W3207156777 cites W2096193424 @default.
• W3207156777 cites W2097174964 @default.
• W3207156777 cites W2097286797 @default.
• W3207156777 cites W2099093610 @default.
• W3207156777 cites W2103950684 @default.
• W3207156777 cites W2104316455 @default.
• W3207156777 cites W2105646011 @default.
• W3207156777 cites W2106303814 @default.
• W3207156777 cites W2106703642 @default.
• W3207156777 cites W2109198113 @default.
• W3207156777 cites W2113744471 @default.
• W3207156777 cites W2114949397 @default.
• W3207156777 cites W2117820592 @default.
• W3207156777 cites W2121483340 @default.
• W3207156777 cites W2128267299 @default.
• W3207156777 cites W2130981336 @default.
• W3207156777 cites W2131092630 @default.
• W3207156777 cites W2132443457 @default.
• W3207156777 cites W2133542546 @default.
• W3207156777 cites W2138645383 @default.
• W3207156777 cites W2138677837 @default.
• W3207156777 cites W2143365093 @default.
• W3207156777 cites W2145746253 @default.
• W3207156777 cites W2157204902 @default.
• W3207156777 cites W2162878054 @default.
• W3207156777 cites W2295784524 @default.
• W3207156777 cites W2414425821 @default.
• W3207156777 cites W2588084912 @default.
• W3207156777 cites W2911723925 @default.
• W3207156777 cites W2914843632 @default.
• W3207156777 cites W2940505353 @default.
• W3207156777 cites W2971465378 @default.
• W3207156777 cites W3007221657 @default.
• W3207156777 cites W3065157603 @default.
• W3207156777 cites W3094141692 @default.
• W3207156777 cites W3117357262 @default.
• W3207156777 cites W3146332038 @default.
• W3207156777 cites W4245935093 @default.

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