FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207178698> ?p ?o ?g. }

• W3207178698 endingPage "769" @default.
• W3207178698 startingPage "757" @default.
• W3207178698 abstract "Cholinergic-induced status epilepticus (SE) is associated with a loss of synaptic gamma-aminobutyric acid A receptors (GABAA R) and an increase in N-methyl-D-aspartate receptors (NMDAR) and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) that may contribute to pharmacoresistance when treatment with benzodiazepine antiseizure medication is delayed. The barbiturate phenobarbital enhances inhibitory neurotransmission by binding to a specific site in the GABAA R to increase the open state of the channel, decrease neuronal excitability, and reduce glutamate-induced currents through AMPA/kainate receptors. We hypothesized that phenobarbital as an adjunct to midazolam would augment the amelioration of soman-induced SE and associated neuropathological changes and that further protection would be provided by the addition of an NMDAR antagonist.We investigated the efficacy of combining antiseizure medications to include a benzodiazepine and a barbiturate allosteric GABAA R modulator (midazolam and phenobarbital, respectively) to correct loss of inhibition, and ketamine to reduce excitation caused by increased synaptic localization of NMDAR and AMPAR, which are NMDA-dependent. Rats implanted with transmitters to record electroencephalographic (EEG) activity were exposed to soman and treated with atropine sulfate and HI-6 one min after exposure and with antiseizure medication(s) 40 minutes after seizure onset.The triple therapy combination of phenobarbital, midazolam, and ketamine administered at 40 minutes after seizure onset effectively prevented soman-induced epileptogenesis and reduced neurodegeneration. In addition, dual therapy with phenobarbital and midazolam or ketamine was more effective than monotherapy (midazolam or phenobarbital) in reducing cholinergic-induced toxicity.Benzodiazepine efficacy is drastically reduced with time after seizure onset and inversely related to seizure duration. To overcome pharmacoresistance in severe benzodiazepine-refractory cholinergic-induced SE, simultaneous drug combination to include drugs that target both the loss of inhibition (eg, midazolam, phenobarbital) and the increased excitatory response (eg, ketamine) is more effective than benzodiazepine or barbiturate monotherapy." @default.
• W3207178698 created "2021-10-25" @default.
• W3207178698 creator A5022823490 @default.
• W3207178698 creator A5029244307 @default.
• W3207178698 creator A5045520666 @default.
• W3207178698 creator A5050881557 @default.
• W3207178698 creator A5062286278 @default.
• W3207178698 creator A5083203431 @default.
• W3207178698 creator A5086125637 @default.
• W3207178698 date "2021-10-23" @default.
• W3207178698 modified "2023-10-16" @default.
• W3207178698 title "Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats" @default.
• W3207178698 cites W1087116711 @default.
• W3207178698 cites W14762853 @default.
• W3207178698 cites W1541490300 @default.
• W3207178698 cites W1968586112 @default.
• W3207178698 cites W1969047674 @default.
• W3207178698 cites W1978022925 @default.
• W3207178698 cites W1978522055 @default.
• W3207178698 cites W1981112783 @default.
• W3207178698 cites W1985636734 @default.
• W3207178698 cites W1989867719 @default.
• W3207178698 cites W1993333230 @default.
• W3207178698 cites W2009277684 @default.
• W3207178698 cites W2014459302 @default.
• W3207178698 cites W2018339284 @default.
• W3207178698 cites W2029095821 @default.
• W3207178698 cites W2031849673 @default.
• W3207178698 cites W2033366759 @default.
• W3207178698 cites W2040574849 @default.
• W3207178698 cites W2040704217 @default.
• W3207178698 cites W2066731397 @default.
• W3207178698 cites W2071542329 @default.
• W3207178698 cites W2073708629 @default.
• W3207178698 cites W2079257658 @default.
• W3207178698 cites W2096428903 @default.
• W3207178698 cites W2103433759 @default.
• W3207178698 cites W2103946141 @default.
• W3207178698 cites W2116394679 @default.
• W3207178698 cites W2211631996 @default.
• W3207178698 cites W2417125435 @default.
• W3207178698 cites W2464816818 @default.
• W3207178698 cites W2474255262 @default.
• W3207178698 cites W2507902224 @default.
• W3207178698 cites W2609553079 @default.
• W3207178698 cites W2794846449 @default.
• W3207178698 cites W2889482212 @default.
• W3207178698 cites W2898508495 @default.
• W3207178698 cites W2917725724 @default.
• W3207178698 cites W2922964398 @default.
• W3207178698 cites W2940650207 @default.
• W3207178698 cites W2969401728 @default.
• W3207178698 cites W2980053974 @default.
• W3207178698 cites W2981179451 @default.
• W3207178698 cites W3005152784 @default.
• W3207178698 cites W3011906001 @default.
• W3207178698 cites W3011961660 @default.
• W3207178698 cites W3036478257 @default.
• W3207178698 cites W3082569727 @default.
• W3207178698 cites W3113445874 @default.
• W3207178698 cites W3132452654 @default.
• W3207178698 cites W3207178698 @default.
• W3207178698 doi "https://doi.org/10.1002/epi4.12552" @default.
• W3207178698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34657398" @default.
• W3207178698 hasPublicationYear "2021" @default.
• W3207178698 type Work @default.
• W3207178698 sameAs 3207178698 @default.
• W3207178698 citedByCount "10" @default.
• W3207178698 countsByYear W32071786982021 @default.
• W3207178698 countsByYear W32071786982022 @default.
• W3207178698 countsByYear W32071786982023 @default.
• W3207178698 crossrefType "journal-article" @default.
• W3207178698 hasAuthorship W3207178698A5022823490 @default.
• W3207178698 hasAuthorship W3207178698A5029244307 @default.
• W3207178698 hasAuthorship W3207178698A5045520666 @default.
• W3207178698 hasAuthorship W3207178698A5050881557 @default.
• W3207178698 hasAuthorship W3207178698A5062286278 @default.
• W3207178698 hasAuthorship W3207178698A5083203431 @default.
• W3207178698 hasAuthorship W3207178698A5086125637 @default.
• W3207178698 hasBestOaLocation W32071786983 @default.
• W3207178698 hasConcept C126322002 @default.
• W3207178698 hasConcept C15744967 @default.
• W3207178698 hasConcept C160268369 @default.
• W3207178698 hasConcept C168258287 @default.
• W3207178698 hasConcept C169760540 @default.
• W3207178698 hasConcept C170493617 @default.
• W3207178698 hasConcept C181199279 @default.
• W3207178698 hasConcept C185592680 @default.
• W3207178698 hasConcept C189184402 @default.
• W3207178698 hasConcept C2776814716 @default.
• W3207178698 hasConcept C2777341932 @default.
• W3207178698 hasConcept C2778000748 @default.
• W3207178698 hasConcept C2778173252 @default.
• W3207178698 hasConcept C2778186239 @default.
• W3207178698 hasConcept C2778409475 @default.
• W3207178698 hasConcept C2778793413 @default.
• W3207178698 hasConcept C2778816929 @default.
• W3207178698 hasConcept C2780077838 @default.

• next