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- W3207221120 abstract "During the COVID-19 pandemic, a 43-year-old male patient with no clinically relevant changes, underwent routine examinations at the Brazilian Army Institute of Biology on 25 May 2021. The fourth-generation chemiluminescence assay, Vitros HIV Combo (Ortho Clinical Diagnostics, New Jersey, USA), for HIV-1 and HIV-2 was performed. The Vitros HIV Combo test detects both HIV-1 and HIV-2 antibodies and the p24 antigen in acute cases of HIV infection. The result obtained was 2.54 s/CO (sample relative light unit/cut-off relative light unit). Specimens with s/CO values of ≥1 are considered reactive for HIV. Following the flowchart established by the Technical Manual for the Diagnosis of HIV Infection in Adults and Children, prepared by the Brazilian Health Ministry,1 a new sample was obtained on 4 June 2021, for confirmation and additional quantification of HIV-1 viral load using real-time reverse transcription PCR (M2000sp and M2000rt; Laboratories, Abbott Park, Illinois, USA) and an antibody specific search for viral HIV-1 antigens (p17, p24, p31, gp41, p51, p55, p66 and gp120/160) using western blotting. The new chemiluminescent HIV-1/HIV12 test showed reactivity at 2.67 s/CO, similar to the first …" @default.
- W3207221120 created "2021-10-25" @default.
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- W3207221120 date "2021-10-21" @default.
- W3207221120 modified "2023-10-06" @default.
- W3207221120 title "Letter to the editor: additional evidence to support a cross-reactivity of SARS-CoV-2 with HIV chemiluminescent assay" @default.
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- W3207221120 doi "https://doi.org/10.1136/jclinpath-2021-207813" @default.
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