Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207227589> ?p ?o ?g. }
- W3207227589 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide, and survival rates have barely improved in decades. In the era of precision medicine, treatment strategies tailored to disease mutations have revolutionized cancer therapy. Next generation sequencing has found that up to a third of all PDAC tumors contain deleterious mutations in DNA damage repair (DDR) genes, highlighting the importance of these genes in PDAC. The mechanisms by which DDR gene mutations promote tumorigenesis, therapeutic response, and subsequent resistance are still not fully understood. Therefore, an opportunity exists to elucidate these processes and to uncover relevant therapeutic drug combinations and strategies to target DDR deficiency in PDAC. However, a constraint to preclinical research is due to limitations in appropriate laboratory experimental models. Models that effectively recapitulate their original cancer tend to provide high levels of predictivity and effective translation of preclinical findings to the clinic. In this review, we outline the occurrence and role of DDR deficiency in PDAC and provide an overview of clinical trials that target these pathways and the preclinical models such as 2D cell lines, 3D organoids and mouse models [genetically engineered mouse model (GEMM), and patient-derived xenograft (PDX)] used in PDAC DDR deficiency research." @default.
- W3207227589 created "2021-10-25" @default.
- W3207227589 creator A5016982974 @default.
- W3207227589 creator A5044315981 @default.
- W3207227589 creator A5057803141 @default.
- W3207227589 creator A5070980157 @default.
- W3207227589 creator A5076159971 @default.
- W3207227589 date "2021-10-12" @default.
- W3207227589 modified "2023-09-27" @default.
- W3207227589 title "DNA Damage Repair Deficiency in Pancreatic Ductal Adenocarcinoma: Preclinical Models and Clinical Perspectives" @default.
- W3207227589 cites W119540838 @default.
- W3207227589 cites W1497915798 @default.
- W3207227589 cites W1547880281 @default.
- W3207227589 cites W1987313243 @default.
- W3207227589 cites W1992995822 @default.
- W3207227589 cites W1997328205 @default.
- W3207227589 cites W2003415831 @default.
- W3207227589 cites W2004125597 @default.
- W3207227589 cites W2006766434 @default.
- W3207227589 cites W2013895149 @default.
- W3207227589 cites W2040252009 @default.
- W3207227589 cites W2064906202 @default.
- W3207227589 cites W2066135299 @default.
- W3207227589 cites W2067117419 @default.
- W3207227589 cites W2085770388 @default.
- W3207227589 cites W2089705824 @default.
- W3207227589 cites W2097124161 @default.
- W3207227589 cites W2105589846 @default.
- W3207227589 cites W2111895881 @default.
- W3207227589 cites W2112474929 @default.
- W3207227589 cites W2117692326 @default.
- W3207227589 cites W2121382392 @default.
- W3207227589 cites W2125026963 @default.
- W3207227589 cites W2146849323 @default.
- W3207227589 cites W2151253787 @default.
- W3207227589 cites W2152061559 @default.
- W3207227589 cites W2154790710 @default.
- W3207227589 cites W2163032348 @default.
- W3207227589 cites W2165045190 @default.
- W3207227589 cites W2165480504 @default.
- W3207227589 cites W2168992025 @default.
- W3207227589 cites W2169509924 @default.
- W3207227589 cites W2262915357 @default.
- W3207227589 cites W2267406903 @default.
- W3207227589 cites W2285093314 @default.
- W3207227589 cites W2332151206 @default.
- W3207227589 cites W2343455000 @default.
- W3207227589 cites W2405114290 @default.
- W3207227589 cites W2413822546 @default.
- W3207227589 cites W2519579947 @default.
- W3207227589 cites W2554987853 @default.
- W3207227589 cites W2561005546 @default.
- W3207227589 cites W2587905891 @default.
- W3207227589 cites W2597062310 @default.
- W3207227589 cites W2606300389 @default.
- W3207227589 cites W2606569138 @default.
- W3207227589 cites W2627028248 @default.
- W3207227589 cites W2745136073 @default.
- W3207227589 cites W2752115770 @default.
- W3207227589 cites W2769127580 @default.
- W3207227589 cites W2772996285 @default.
- W3207227589 cites W2775300375 @default.
- W3207227589 cites W2783113646 @default.
- W3207227589 cites W2783439822 @default.
- W3207227589 cites W2793698150 @default.
- W3207227589 cites W2807088563 @default.
- W3207227589 cites W2807759451 @default.
- W3207227589 cites W2807942883 @default.
- W3207227589 cites W2808191072 @default.
- W3207227589 cites W2808408940 @default.
- W3207227589 cites W2888369063 @default.
- W3207227589 cites W2889433609 @default.
- W3207227589 cites W2891977847 @default.
- W3207227589 cites W2895926103 @default.
- W3207227589 cites W2922764110 @default.
- W3207227589 cites W2932374721 @default.
- W3207227589 cites W2946919317 @default.
- W3207227589 cites W2947826965 @default.
- W3207227589 cites W2950430797 @default.
- W3207227589 cites W2971567983 @default.
- W3207227589 cites W2979274575 @default.
- W3207227589 cites W2983879675 @default.
- W3207227589 cites W2985148590 @default.
- W3207227589 cites W2987427797 @default.
- W3207227589 cites W2993258893 @default.
- W3207227589 cites W2993993303 @default.
- W3207227589 cites W2999417355 @default.
- W3207227589 cites W3001200992 @default.
- W3207227589 cites W3001713806 @default.
- W3207227589 cites W3004469426 @default.
- W3207227589 cites W3013413945 @default.
- W3207227589 cites W3024280699 @default.
- W3207227589 cites W3028400974 @default.
- W3207227589 cites W3042953038 @default.
- W3207227589 cites W3080980743 @default.
- W3207227589 cites W3082138527 @default.
- W3207227589 cites W3085320201 @default.
- W3207227589 cites W3091421761 @default.
- W3207227589 cites W3092288940 @default.
- W3207227589 cites W3097851508 @default.