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- W3207231638 endingPage "5026" @default.
- W3207231638 startingPage "5026" @default.
- W3207231638 abstract "Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are hematologic malignancies arising from the bone marrow. Despite recent advances in treating these diseases, patients with higher-risk MDS and AML continue to have a poor prognosis with limited survival. It has long been recognized that there is an immune component to the pathogenesis of MDS and AML, but until recently, immune therapies have played a limited role in treating these diseases. Immune suppressive therapy exhibits durable clinical responses in selected patients with MDS, but the question of which patients are most suitable for this treatment remains unclear. Over the past decade, there has been remarkable progress in identifying genomic features of MDS and AML, which has led to an improved discernment of the molecular pathogenesis of these diseases. An improved understanding of immune and inflammatory molecular mechanisms of MDS and AML have also recently revealed novel therapeutic targets. Emerging treatments for MDS and AML include monoclonal antibodies such as immune checkpoint inhibitors, bispecific T-cell-engaging antibodies, antibody drug conjugates, vaccine therapies, and cellular therapeutics including chimeric antigen receptor T-cells and NK cells. In this review, we provide an overview of the current understanding of immune dysregulation in MDS and AML and an update on novel immune therapies for these bone marrow malignancies." @default.
- W3207231638 created "2021-10-25" @default.
- W3207231638 creator A5033698905 @default.
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- W3207231638 creator A5058505297 @default.
- W3207231638 creator A5060669048 @default.
- W3207231638 creator A5076119672 @default.
- W3207231638 date "2021-10-08" @default.
- W3207231638 modified "2023-09-27" @default.
- W3207231638 title "Immune Therapies for Myelodysplastic Syndromes and Acute Myeloid Leukemia" @default.
- W3207231638 cites W1171241794 @default.
- W3207231638 cites W1821781403 @default.
- W3207231638 cites W1904298553 @default.
- W3207231638 cites W1906337113 @default.
- W3207231638 cites W1932173779 @default.
- W3207231638 cites W1967949472 @default.
- W3207231638 cites W1975558291 @default.
- W3207231638 cites W1978659582 @default.
- W3207231638 cites W1979882109 @default.
- W3207231638 cites W1983973479 @default.
- W3207231638 cites W1985685212 @default.
- W3207231638 cites W1985970823 @default.
- W3207231638 cites W1986358260 @default.
- W3207231638 cites W1999212901 @default.
- W3207231638 cites W2000112238 @default.
- W3207231638 cites W2002200762 @default.
- W3207231638 cites W2002478729 @default.
- W3207231638 cites W2006111046 @default.
- W3207231638 cites W2011581543 @default.
- W3207231638 cites W2018317651 @default.
- W3207231638 cites W2019932788 @default.
- W3207231638 cites W2021588881 @default.
- W3207231638 cites W2022505130 @default.
- W3207231638 cites W2025338891 @default.
- W3207231638 cites W2026373761 @default.
- W3207231638 cites W2029487277 @default.
- W3207231638 cites W2037576870 @default.
- W3207231638 cites W2038369321 @default.
- W3207231638 cites W2041965576 @default.
- W3207231638 cites W2043747739 @default.
- W3207231638 cites W2052502668 @default.
- W3207231638 cites W2056093991 @default.
- W3207231638 cites W2070332120 @default.
- W3207231638 cites W2071523891 @default.
- W3207231638 cites W2071908402 @default.
- W3207231638 cites W2077217249 @default.
- W3207231638 cites W2079713295 @default.
- W3207231638 cites W2082919098 @default.
- W3207231638 cites W2089881927 @default.
- W3207231638 cites W2091193918 @default.
- W3207231638 cites W2097126393 @default.
- W3207231638 cites W2108207655 @default.
- W3207231638 cites W2111063688 @default.
- W3207231638 cites W2129049052 @default.
- W3207231638 cites W2131095909 @default.
- W3207231638 cites W2132327973 @default.
- W3207231638 cites W2135399946 @default.
- W3207231638 cites W2137881702 @default.
- W3207231638 cites W2142548447 @default.
- W3207231638 cites W2144770839 @default.
- W3207231638 cites W2146862320 @default.
- W3207231638 cites W2165954541 @default.
- W3207231638 cites W2245059224 @default.
- W3207231638 cites W2259204994 @default.
- W3207231638 cites W2264982566 @default.
- W3207231638 cites W2273962941 @default.
- W3207231638 cites W2279093595 @default.
- W3207231638 cites W2326726820 @default.
- W3207231638 cites W2333714736 @default.
- W3207231638 cites W2339658711 @default.
- W3207231638 cites W2356002586 @default.
- W3207231638 cites W2409362639 @default.
- W3207231638 cites W2417431203 @default.
- W3207231638 cites W2417508398 @default.
- W3207231638 cites W2417767096 @default.
- W3207231638 cites W2418753377 @default.
- W3207231638 cites W2439051852 @default.
- W3207231638 cites W2465734185 @default.
- W3207231638 cites W2510502610 @default.
- W3207231638 cites W2517076746 @default.
- W3207231638 cites W2530814271 @default.
- W3207231638 cites W2556838184 @default.
- W3207231638 cites W2558172881 @default.
- W3207231638 cites W2561437388 @default.
- W3207231638 cites W2585106732 @default.
- W3207231638 cites W2590534615 @default.
- W3207231638 cites W2619107737 @default.
- W3207231638 cites W2715749014 @default.
- W3207231638 cites W2751871114 @default.
- W3207231638 cites W2753778520 @default.
- W3207231638 cites W2758263899 @default.
- W3207231638 cites W2768799228 @default.
- W3207231638 cites W2782108932 @default.
- W3207231638 cites W2782350444 @default.
- W3207231638 cites W2790461174 @default.
- W3207231638 cites W2800050586 @default.
- W3207231638 cites W2803116026 @default.
- W3207231638 cites W2804727484 @default.