FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207238574> ?p ?o ?g. }

• W3207238574 endingPage "103476" @default.
• W3207238574 startingPage "103476" @default.
• W3207238574 abstract "This work explored the protective effects of nucleosides rich extract from C. cicadae (CCNE) against cisplatin-induced neurotoxicity. The rats were divided into four groups: normal control (NCA), cisplatin control (CCA), CCNE-L + cisplatin (CCNE-L) and CCNE-H + cisplatin (CCNE-H). The rats in CCNE-L and CCNE-H were orally administered with 100 and 400 mg/kg of CCNE, respectively for five weeks, while the rats in CCA, CCNE-L and CCNE-H groups received intraperitoneal injection of 2.5 mg/kg cisplatin once a week for four weeks starting from the second week of CCNE treatment. After the final treatment, the rats were subjected to behavioural task including Morris water maze test (MWMT), Y maze test, forced swimming (FST), open field test (OFT), rotarod test as well as heat and mechanical hyperalgesia test. Thereafter, the animals were sacrificed and oxidative stress biomarkers, inflammatory mediators and acetylcholinesterase activities were measured in the brain. The histopathological assessment of the brain issues was also performed using H&E staining. The results indicated that CCNE significantly ameliorative cisplatin induced learning and memory impairment (MWMT and Y maze test), depressive behaviours (FST and OFT), motor coordination as well as thermal (hot plate and tail withdrawal test) and mechanical hyperalgesia (von Frey filament test). Furthermore, CCNE decreased acetylcholinesterase level, proinflammatory cytokines levels and lipid peroxidation, with concomitant increase in antioxidant enzymes profiles in the brain tissues of cisplatin treated rats. Additionally, CCNE treatment alleviated histopathological alterations in the brain tissues caused by cisplatin treatment. These results suggested that CCNE ameliorated memory impairment deficits, neuropathy, increased oxidative stress, inflammation in cisplatin treated rats through the inhibition of oxidative stress and inflammation." @default.
• W3207238574 created "2021-10-25" @default.
• W3207238574 creator A5016916051 @default.
• W3207238574 creator A5036437037 @default.
• W3207238574 creator A5063818269 @default.
• W3207238574 creator A5065164194 @default.
• W3207238574 date "2022-01-01" @default.
• W3207238574 modified "2023-09-25" @default.
• W3207238574 title "Nucleosides rich extract from Cordyceps cicadae alleviated cisplatin-induced neurotoxicity in rats: A behavioral, biochemical and histopathological study" @default.
• W3207238574 cites W161606654 @default.
• W3207238574 cites W1832113570 @default.
• W3207238574 cites W1971048984 @default.
• W3207238574 cites W1982749330 @default.
• W3207238574 cites W1984246967 @default.
• W3207238574 cites W1993397541 @default.
• W3207238574 cites W2009929398 @default.
• W3207238574 cites W2019164555 @default.
• W3207238574 cites W2062039044 @default.
• W3207238574 cites W2063712784 @default.
• W3207238574 cites W2087401864 @default.
• W3207238574 cites W2089299823 @default.
• W3207238574 cites W2143341124 @default.
• W3207238574 cites W2326999355 @default.
• W3207238574 cites W2463236959 @default.
• W3207238574 cites W2481624906 @default.
• W3207238574 cites W2521574223 @default.
• W3207238574 cites W2558267228 @default.
• W3207238574 cites W2586488834 @default.
• W3207238574 cites W2738575330 @default.
• W3207238574 cites W2749485000 @default.
• W3207238574 cites W2752748470 @default.
• W3207238574 cites W2792174611 @default.
• W3207238574 cites W2804776044 @default.
• W3207238574 cites W2810601357 @default.
• W3207238574 cites W2896668430 @default.
• W3207238574 cites W2898063253 @default.
• W3207238574 cites W2901297849 @default.
• W3207238574 cites W2904217420 @default.
• W3207238574 cites W2915535851 @default.
• W3207238574 cites W2937196979 @default.
• W3207238574 cites W2947913329 @default.
• W3207238574 cites W2949333767 @default.
• W3207238574 cites W2966431516 @default.
• W3207238574 cites W2966470922 @default.
• W3207238574 cites W2966842106 @default.
• W3207238574 cites W2968991229 @default.
• W3207238574 cites W2982135574 @default.
• W3207238574 cites W2991033820 @default.
• W3207238574 cites W2997951819 @default.
• W3207238574 cites W3004189906 @default.
• W3207238574 cites W3004780772 @default.
• W3207238574 cites W3009385450 @default.
• W3207238574 cites W3016928764 @default.
• W3207238574 cites W3024065332 @default.
• W3207238574 cites W3024320782 @default.
• W3207238574 cites W3043763767 @default.
• W3207238574 cites W3080231341 @default.
• W3207238574 cites W3090745069 @default.
• W3207238574 cites W3094384494 @default.
• W3207238574 cites W3104979374 @default.
• W3207238574 cites W3105897094 @default.
• W3207238574 cites W3128677211 @default.
• W3207238574 cites W3130200144 @default.
• W3207238574 cites W3133882691 @default.
• W3207238574 cites W3136338320 @default.
• W3207238574 cites W3156214565 @default.
• W3207238574 cites W3162406517 @default.
• W3207238574 doi "https://doi.org/10.1016/j.arabjc.2021.103476" @default.
• W3207238574 hasPublicationYear "2022" @default.
• W3207238574 type Work @default.
• W3207238574 sameAs 3207238574 @default.
• W3207238574 citedByCount "3" @default.
• W3207238574 countsByYear W32072385742022 @default.
• W3207238574 countsByYear W32072385742023 @default.
• W3207238574 crossrefType "journal-article" @default.
• W3207238574 hasAuthorship W3207238574A5016916051 @default.
• W3207238574 hasAuthorship W3207238574A5036437037 @default.
• W3207238574 hasAuthorship W3207238574A5063818269 @default.
• W3207238574 hasAuthorship W3207238574A5065164194 @default.
• W3207238574 hasBestOaLocation W32072385741 @default.
• W3207238574 hasConcept C118552586 @default.
• W3207238574 hasConcept C126322002 @default.
• W3207238574 hasConcept C134018914 @default.
• W3207238574 hasConcept C136569192 @default.
• W3207238574 hasConcept C164027704 @default.
• W3207238574 hasConcept C173586616 @default.
• W3207238574 hasConcept C178790620 @default.
• W3207238574 hasConcept C181199279 @default.
• W3207238574 hasConcept C185592680 @default.
• W3207238574 hasConcept C2776151105 @default.
• W3207238574 hasConcept C2776694085 @default.
• W3207238574 hasConcept C2776914184 @default.
• W3207238574 hasConcept C2777981454 @default.
• W3207238574 hasConcept C2778004101 @default.
• W3207238574 hasConcept C2778239845 @default.
• W3207238574 hasConcept C2778816929 @default.
• W3207238574 hasConcept C2779059548 @default.
• W3207238574 hasConcept C2779085643 @default.

• next