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- W3207277076 abstract "Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations exhibit an unfavorable response to PD-1 inhibitor through unclear mechanisms. Hypothesizing that EGFR mutations alter tumor-immune interactions, we compare tumor-infiltrating lymphocytes between EGFR mutant (EGFR-MT) and wild type (EGFR-WT) tumors through single-cell transcriptomic analysis. We find that B cells, CXCL13-producing follicular helper CD4+ T (TFH)-like cells, and tissue-resident memory CD8+ T (TRM)-like cells decreased in EGFR-MT tumors. The NOTCH-RBPJ regulatory network, which is vital for persistence of TRM state, is perturbed, and the interactions between TFH and B cells through the CXCL13-CXCR5 axis disappear in EGFR-MT tumors. Notably, the proportion of TRM-like cells is predictive for anti-PD-1 response in NSCLC. Our findings suggest that the impairment of TFH-B-TRM cooperation in tertiary lymphoid structure formation, accompanied by the dysregulation of TRM homeostasis and the loss of TFH-B crosstalk, underlies unfavorable anti-PD-1 response in EGFR-MT lung tumors." @default.
- W3207277076 created "2021-10-25" @default.
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- W3207277076 date "2021-10-18" @default.
- W3207277076 modified "2023-10-17" @default.
- W3207277076 title "Dysregulation of TFH-B-TRM lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer" @default.
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- W3207277076 cites W2117696681 @default.
- W3207277076 cites W2156353875 @default.
- W3207277076 cites W2163844751 @default.
- W3207277076 cites W2180481128 @default.
- W3207277076 cites W2198093519 @default.
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- W3207277076 cites W2804242740 @default.
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- W3207277076 doi "https://doi.org/10.1038/s41467-021-26362-0" @default.
- W3207277076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8523541" @default.
- W3207277076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34663810" @default.
- W3207277076 hasPublicationYear "2021" @default.
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