FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207284814> ?p ?o ?g. }

• W3207284814 endingPage "S105" @default.
• W3207284814 startingPage "S104" @default.
• W3207284814 abstract "BACKGROUND Truncal valve insufficiency (TVI) not only is one of the risk factors for death in neonatal primary repair for common arterial trunk (CAT), but also influences long-term left ventricular performance. This study investigates the functional and survival outcomes of CAT repair in patients based on TVI severity. METHODS AND RESULTS In this single-center retrospective case-matched controlled study, 16 consecutive CAT patients from 2000- 2018 with moderate to severe truncal valve regurgitation (TVR2-3) undergoing primary CAT surgery with truncal valve (TrV) repair were matched to 16 CAT patients with none to mild truncal valve regurgitation (TVR1-0). Survival was analyzed using Kaplan-Meier; reintervention using competing risks; paired tests for ventricular function and geometry, and health status. TVR2-3 group had 11 (69%) patients with moderate TVR and 5 (31%) patients with severe TVI, with operative median age of 7(4 – 19) days. The TVR1-0 group had 3 (19%) patients with none/trivial TVI and 13 (81%) patients with mild TVI, with an operative median age of 132(6– 22) days (p = 0.30). There were no significant differences in preoperative variables between the groups and repair technique as shown in Table 1. There was no significant difference between overall survival and modified Ross heart failure score at median length of follow-up of 9.17 (1.40 – 15.12) years. Rate of surgical TrV reintervention at 5 years postoperative was 8% and 67% for TVR0-1 and TVR2-3, respectively (Stratified Gray's p = 0.005). TVR2-3 experienced greater residual TVI at discharge and 1 year post-repair with severity of TrV dysfunction converging between groups as more patients in TVR0-1 developed mild/moderate TVI over time and TVR2-3 patients underwent reintervention. Left ventricular ejection fraction (LVEF) was comparable between groups at all time-points, with the exception of postoperative year 1 [TVR0-1: 69(67 – 74)% vs. TVR2-3: 62(59 – 66)% (p = 0.006) Figure 1]. Although not statistically significant, pronounced left ventricular dilatation was seen in the TVR2-3 group (upper quartile, z-score +6) throughout 1-year post-repair. Increasing left ventricular size in TVR2-3 reached statistical significance at 3 (p = 0.001) and 5 years (p = 0.003), but did not impair LVEF. CONCLUSION There was a greater number of surgical TrV reinterventions (i.e. repair or replacement) in the TVR2-3 population, with two deaths associated with critical residual TVI refractory to reintervention. Progressive left ventricular dilatation in the TVR2-3 group due to residual TVI was well tolerated. Ventricular remodeling did not significantly impact left ventricular function or clinical status. Truncal valve insufficiency (TVI) not only is one of the risk factors for death in neonatal primary repair for common arterial trunk (CAT), but also influences long-term left ventricular performance. This study investigates the functional and survival outcomes of CAT repair in patients based on TVI severity. In this single-center retrospective case-matched controlled study, 16 consecutive CAT patients from 2000- 2018 with moderate to severe truncal valve regurgitation (TVR2-3) undergoing primary CAT surgery with truncal valve (TrV) repair were matched to 16 CAT patients with none to mild truncal valve regurgitation (TVR1-0). Survival was analyzed using Kaplan-Meier; reintervention using competing risks; paired tests for ventricular function and geometry, and health status. TVR2-3 group had 11 (69%) patients with moderate TVR and 5 (31%) patients with severe TVI, with operative median age of 7(4 – 19) days. The TVR1-0 group had 3 (19%) patients with none/trivial TVI and 13 (81%) patients with mild TVI, with an operative median age of 132(6– 22) days (p = 0.30). There were no significant differences in preoperative variables between the groups and repair technique as shown in Table 1. There was no significant difference between overall survival and modified Ross heart failure score at median length of follow-up of 9.17 (1.40 – 15.12) years. Rate of surgical TrV reintervention at 5 years postoperative was 8% and 67% for TVR0-1 and TVR2-3, respectively (Stratified Gray's p = 0.005). TVR2-3 experienced greater residual TVI at discharge and 1 year post-repair with severity of TrV dysfunction converging between groups as more patients in TVR0-1 developed mild/moderate TVI over time and TVR2-3 patients underwent reintervention. Left ventricular ejection fraction (LVEF) was comparable between groups at all time-points, with the exception of postoperative year 1 [TVR0-1: 69(67 – 74)% vs. TVR2-3: 62(59 – 66)% (p = 0.006) Figure 1]. Although not statistically significant, pronounced left ventricular dilatation was seen in the TVR2-3 group (upper quartile, z-score +6) throughout 1-year post-repair. Increasing left ventricular size in TVR2-3 reached statistical significance at 3 (p = 0.001) and 5 years (p = 0.003), but did not impair LVEF. There was a greater number of surgical TrV reinterventions (i.e. repair or replacement) in the TVR2-3 population, with two deaths associated with critical residual TVI refractory to reintervention. Progressive left ventricular dilatation in the TVR2-3 group due to residual TVI was well tolerated. Ventricular remodeling did not significantly impact left ventricular function or clinical status." @default.
• W3207284814 created "2021-10-25" @default.
• W3207284814 creator A5004093435 @default.
• W3207284814 creator A5025330560 @default.
• W3207284814 creator A5037412172 @default.
• W3207284814 creator A5054403452 @default.
• W3207284814 creator A5076588558 @default.
• W3207284814 creator A5082443993 @default.
• W3207284814 date "2021-10-01" @default.
• W3207284814 modified "2023-09-23" @default.
• W3207284814 title "IMPACT OF TRUNCAL VALVE REGURGITATION ON LEFT VENTRICULAR FUNCTION AND GEOMETRY IN COMMON ARTERIAL TRUNK: A CASE-MATCH CONTROLLED STUDY" @default.
• W3207284814 doi "https://doi.org/10.1016/j.cjca.2021.07.202" @default.
• W3207284814 hasPublicationYear "2021" @default.
• W3207284814 type Work @default.
• W3207284814 sameAs 3207284814 @default.
• W3207284814 citedByCount "0" @default.
• W3207284814 crossrefType "journal-article" @default.
• W3207284814 hasAuthorship W3207284814A5004093435 @default.
• W3207284814 hasAuthorship W3207284814A5025330560 @default.
• W3207284814 hasAuthorship W3207284814A5037412172 @default.
• W3207284814 hasAuthorship W3207284814A5054403452 @default.
• W3207284814 hasAuthorship W3207284814A5076588558 @default.
• W3207284814 hasAuthorship W3207284814A5082443993 @default.
• W3207284814 hasConcept C126322002 @default.
• W3207284814 hasConcept C141071460 @default.
• W3207284814 hasConcept C164705383 @default.
• W3207284814 hasConcept C167135981 @default.
• W3207284814 hasConcept C18903297 @default.
• W3207284814 hasConcept C2780073493 @default.
• W3207284814 hasConcept C2780168065 @default.
• W3207284814 hasConcept C2781197403 @default.
• W3207284814 hasConcept C71924100 @default.
• W3207284814 hasConcept C86803240 @default.
• W3207284814 hasConceptScore W3207284814C126322002 @default.
• W3207284814 hasConceptScore W3207284814C141071460 @default.
• W3207284814 hasConceptScore W3207284814C164705383 @default.
• W3207284814 hasConceptScore W3207284814C167135981 @default.
• W3207284814 hasConceptScore W3207284814C18903297 @default.
• W3207284814 hasConceptScore W3207284814C2780073493 @default.
• W3207284814 hasConceptScore W3207284814C2780168065 @default.
• W3207284814 hasConceptScore W3207284814C2781197403 @default.
• W3207284814 hasConceptScore W3207284814C71924100 @default.
• W3207284814 hasConceptScore W3207284814C86803240 @default.
• W3207284814 hasIssue "10" @default.
• W3207284814 hasLocation W32072848141 @default.
• W3207284814 hasOpenAccess W3207284814 @default.
• W3207284814 hasPrimaryLocation W32072848141 @default.
• W3207284814 hasRelatedWork W2058489177 @default.
• W3207284814 hasRelatedWork W2145197935 @default.
• W3207284814 hasRelatedWork W2995728818 @default.
• W3207284814 hasRelatedWork W3139267926 @default.
• W3207284814 hasRelatedWork W4214517713 @default.
• W3207284814 hasRelatedWork W4251102852 @default.
• W3207284814 hasRelatedWork W4287448225 @default.
• W3207284814 hasRelatedWork W4305082178 @default.
• W3207284814 hasRelatedWork W4319440053 @default.
• W3207284814 hasRelatedWork W2588803639 @default.
• W3207284814 hasVolume "37" @default.
• W3207284814 isParatext "false" @default.
• W3207284814 isRetracted "false" @default.
• W3207284814 magId "3207284814" @default.
• W3207284814 workType "article" @default.