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• W3207285964 endingPage "705" @default.
• W3207285964 startingPage "705" @default.
• W3207285964 abstract "I'm Not Dead Yet (Indy) is a fly gene that encodes a homologue of mammalian SLC13A5 plasma membrane citrate transporter. Reducing expression of Indy gene in flies, and its homologues in worms, extends longevity. Indy reduction in flies, worms, mice and rats affects metabolism by regulating the levels of cytoplasmic citrate, inducing a state similar to calorie restriction. Changes include lower lipid levels, increased insulin sensitivity, increased mitochondrial biogenesis, and prevention of weight gain, among others. The INDY protein is predominantly expressed in fly metabolic tissues: the midgut, fat body and oenocytes. Changes in fly midgut metabolism associated with reduced Indy gene activity lead to preserved mitochondrial function and reduced production of reactive oxygen species. All these changes lead to preserved intestinal stem cell homeostasis, which has a key role in maintaining intestinal epithelium function and enhancing fly healthspan and lifespan. Indy gene expression levels change in response to caloric content of the diet, inflammation and aging, suggesting that INDY regulates metabolic adaptation to nutrition or energetic requirements by controlling citrate levels." @default.
• W3207285964 created "2021-10-25" @default.
• W3207285964 creator A5029392275 @default.
• W3207285964 creator A5053156293 @default.
• W3207285964 date "2021-10-15" @default.
• W3207285964 modified "2023-10-14" @default.
• W3207285964 title "The Role of Citrate Transporter INDY in Metabolism and Stem Cell Homeostasis" @default.
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• W3207285964 doi "https://doi.org/10.3390/metabo11100705" @default.
• W3207285964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8540898" @default.
• W3207285964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34677421" @default.

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