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- W3207301939 abstract "During the past decade, there have been considerable advances in understanding of the genetic and morphogenic processes underlying cortical malformations and developmental brain tumours. Focal malformations are caused by somatic (postzygotic) variants in genes related to cell growth (ie, in the mTOR pathway in focal cortical dysplasia type 2), which are acquired in neuronal progenitors during neurodevelopment. In comparison, developmental brain tumours result from somatic variants in genes related to cell proliferation (eg, in the MAP-kinase pathway in ganglioglioma), which affect proliferating glioneuronal precursors. The timing of the genetic event and the specific gene involved during neurodevelopment will drive the nature and size of the lesion, whether it is a developmental malformation or a brain tumour. There is also emerging evidence that epigenetic processes underlie a molecular memory in epileptogenesis. This knowledge will together facilitate understanding of why and how patients with these lesions have epilepsy, and could form a basis for a move towards precision medicine for this challenging cohort of patients." @default.
- W3207301939 created "2021-10-25" @default.
- W3207301939 creator A5010212767 @default.
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- W3207301939 creator A5070118171 @default.
- W3207301939 creator A5082783677 @default.
- W3207301939 creator A5084992398 @default.
- W3207301939 date "2021-11-01" @default.
- W3207301939 modified "2023-10-04" @default.
- W3207301939 title "Neocortical development and epilepsy: insights from focal cortical dysplasia and brain tumours" @default.
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