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- W3207316648 abstract "Transthyretin amyloid cardiomyopathy (ATTR-CM) is potentially a fatal disease characterized by abnormal buildup of amyloid fibrils primarily in the heart causing progressive heart failure. It is categorized into two subtypes-hereditary ATTR and wild type ATTR. Previously, no treatment is available, due to which liver transplantation, multi-organ transplantation, and symptomatic treatment were the only therapies at that time. Approval of Vyndaqel (tafamidis meglumine) and Vyndamax (tafamidis) capsules in 2019, acts like a kick in the research fields due to which other therapeutics are now emerging. Several clinical trials are going on to evaluate the efficacy of different drugs in ATTR-CM. Most of the clinical trials demonstrated positive outcomes which leads to further evaluation for confirmation. In this review treatment pipeline, ongoing clinical trials and challenges related to ATTR-CM are described." @default.
- W3207316648 created "2021-10-25" @default.
- W3207316648 creator A5044863317 @default.
- W3207316648 creator A5056770547 @default.
- W3207316648 date "2021-01-01" @default.
- W3207316648 modified "2023-10-14" @default.
- W3207316648 title "Transthyretin amyloid cardiomyopathy: Treatment pipeline, clinical trials, and challenges" @default.
- W3207316648 doi "https://doi.org/10.4103/jphpc.jphpc_8_21" @default.
- W3207316648 hasPublicationYear "2021" @default.
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