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- W3207351212 abstract "3-<em>O</em>-Acetyl-glycyrrhetinic amides were prepared, and sulforhodamine B assays investigated their cytotoxicity. Their cytotoxicity strongly depended on the substitution pattern of the respective compounds. Thereby, an ethylenediamine-derived compound <strong>2</strong> performed the best, acting mainly by apoptosis. As far as heterocyclic amides are concerned, ring enlargement and the replacement of the distal nitrogen invariably led to a more or less complete loss of cytotoxic activity. Thus, the presence of a carbonyl function (C-30) seems necessary for providing significant cytotoxicity." @default.
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- W3207351212 date "2021-10-16" @default.
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- W3207351212 title "Glycyrrhetinic amides and their cytotoxicity" @default.
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- W3207351212 doi "https://doi.org/10.13171/mjc02110161595cesuk" @default.
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