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• W3207368284 abstract "An embryo experiences progressively complex spatial and temporal patterns of gene expression that guide the morphogenesis of its body plan as it matures. Using super-resolution fluorescence microscopy in Drosophila melanogaster embryos, we observed a similar increase in complexity in the nucleus: the spatial distributions of transcription factors became increasingly heterogeneous as the embryo matured. We also observed a similar trend in chromatin conformation with the establishment of specific histone modification patterns. However, transcription sites of specific genes had distinct local preferences for histone marks separate from the average nuclear trend, depending on the time and location of their expression. These results suggest that reconfiguring the nuclear environment is an integral part of embryogenesis and that the physical organization of the nucleus a key element in developmental gene regulation." @default.
• W3207368284 created "2021-10-25" @default.
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• W3207368284 creator A5073493153 @default.
• W3207368284 date "2021-10-14" @default.
• W3207368284 modified "2023-10-15" @default.
• W3207368284 title "Nuclear morphogenesis: forming a heterogeneous nucleus during embryogenesis" @default.
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• W3207368284 doi "https://doi.org/10.1101/2021.10.14.464356" @default.
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