Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207368664> ?p ?o ?g. }
- W3207368664 abstract "Rhesus macaques are a common non-human primate model used in the evaluation of human monoclonal antibodies, molecules whose effector functions depend on a conserved N-linked glycan in the Fc region. This carbohydrate is a target of glycoengineering efforts aimed at altering antibody effector function by modulating the affinity of Fcγ receptors. For example, a reduction in the overall core fucose content is one such strategy that can increase antibody-mediated cellular cytotoxicity by increasing Fc-FcγRIIIa affinity. While the position of the Fc glycan is conserved in macaques, differences in the frequency of glycoforms and the use of an alternate monosaccharide in sialylated glycan species add a degree of uncertainty to the testing of glycoengineered human antibodies in rhesus macaques. Using a panel of 16 human IgG1 glycovariants, we measured the affinities of macaque FcγRs for differing glycoforms via surface plasmon resonance. Our results suggest that macaques are a tractable species in which to test the effects of antibody glycoengineering." @default.
- W3207368664 created "2021-10-25" @default.
- W3207368664 creator A5001994531 @default.
- W3207368664 creator A5025154426 @default.
- W3207368664 creator A5027226086 @default.
- W3207368664 creator A5031365512 @default.
- W3207368664 creator A5039369938 @default.
- W3207368664 creator A5043451840 @default.
- W3207368664 creator A5044760246 @default.
- W3207368664 creator A5049360221 @default.
- W3207368664 creator A5065397150 @default.
- W3207368664 creator A5071990559 @default.
- W3207368664 date "2021-10-12" @default.
- W3207368664 modified "2023-09-30" @default.
- W3207368664 title "Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors" @default.
- W3207368664 cites W1582075870 @default.
- W3207368664 cites W1656961899 @default.
- W3207368664 cites W1831036856 @default.
- W3207368664 cites W1963778872 @default.
- W3207368664 cites W196745983 @default.
- W3207368664 cites W1969824500 @default.
- W3207368664 cites W1975380390 @default.
- W3207368664 cites W1981971084 @default.
- W3207368664 cites W1988112437 @default.
- W3207368664 cites W1991656907 @default.
- W3207368664 cites W1993262095 @default.
- W3207368664 cites W1993591613 @default.
- W3207368664 cites W2004919864 @default.
- W3207368664 cites W2017523857 @default.
- W3207368664 cites W2023765040 @default.
- W3207368664 cites W2025031903 @default.
- W3207368664 cites W2034498773 @default.
- W3207368664 cites W2035433348 @default.
- W3207368664 cites W2041140334 @default.
- W3207368664 cites W2051666192 @default.
- W3207368664 cites W2052491267 @default.
- W3207368664 cites W2055251699 @default.
- W3207368664 cites W2065163701 @default.
- W3207368664 cites W2073356522 @default.
- W3207368664 cites W2077079182 @default.
- W3207368664 cites W2080942704 @default.
- W3207368664 cites W2084136419 @default.
- W3207368664 cites W2094445987 @default.
- W3207368664 cites W2098488781 @default.
- W3207368664 cites W2111016103 @default.
- W3207368664 cites W2115175735 @default.
- W3207368664 cites W2136564498 @default.
- W3207368664 cites W2137354517 @default.
- W3207368664 cites W2148581517 @default.
- W3207368664 cites W2152155460 @default.
- W3207368664 cites W2154100133 @default.
- W3207368664 cites W2154576279 @default.
- W3207368664 cites W2155379930 @default.
- W3207368664 cites W2172224306 @default.
- W3207368664 cites W2234421491 @default.
- W3207368664 cites W2299193714 @default.
- W3207368664 cites W2415407627 @default.
- W3207368664 cites W2478409189 @default.
- W3207368664 cites W2513199205 @default.
- W3207368664 cites W2521361619 @default.
- W3207368664 cites W2556080091 @default.
- W3207368664 cites W2564315963 @default.
- W3207368664 cites W2581165541 @default.
- W3207368664 cites W2604814997 @default.
- W3207368664 cites W2617806029 @default.
- W3207368664 cites W2741734362 @default.
- W3207368664 cites W2743062554 @default.
- W3207368664 cites W2780288258 @default.
- W3207368664 cites W2802098245 @default.
- W3207368664 cites W2883509466 @default.
- W3207368664 cites W2883979574 @default.
- W3207368664 cites W2897301107 @default.
- W3207368664 cites W2902838323 @default.
- W3207368664 cites W2904713347 @default.
- W3207368664 cites W2936579903 @default.
- W3207368664 cites W3025242944 @default.
- W3207368664 cites W3105885548 @default.
- W3207368664 cites W3106040562 @default.
- W3207368664 cites W3117759033 @default.
- W3207368664 cites W3182005667 @default.
- W3207368664 cites W3195743109 @default.
- W3207368664 cites W74809848 @default.
- W3207368664 cites W87884376 @default.
- W3207368664 doi "https://doi.org/10.3389/fimmu.2021.754710" @default.
- W3207368664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8546228" @default.
- W3207368664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34712242" @default.
- W3207368664 hasPublicationYear "2021" @default.
- W3207368664 type Work @default.
- W3207368664 sameAs 3207368664 @default.
- W3207368664 citedByCount "7" @default.
- W3207368664 countsByYear W32073686642022 @default.
- W3207368664 countsByYear W32073686642023 @default.
- W3207368664 crossrefType "journal-article" @default.
- W3207368664 hasAuthorship W3207368664A5001994531 @default.
- W3207368664 hasAuthorship W3207368664A5025154426 @default.
- W3207368664 hasAuthorship W3207368664A5027226086 @default.
- W3207368664 hasAuthorship W3207368664A5031365512 @default.
- W3207368664 hasAuthorship W3207368664A5039369938 @default.
- W3207368664 hasAuthorship W3207368664A5043451840 @default.
- W3207368664 hasAuthorship W3207368664A5044760246 @default.