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- W3207369947 abstract "Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by persistent deficits in social communication and interaction. Common genetic variation appears to play a key role in the development of this condition. In this systematic review, we describe the relationship between genetic variations and autism. We created a gene dataset of the genes involved in the pathogenesis of autism and performed an over-representation analysis to evaluate the biological functions and molecular pathways that may explain the associations between these variants and the development of ASD.177 studies and a gene set composed of 139 were included in this qualitative systematic review. Enriched pathways in the over-representation analysis using the KEGG pathway database were mostly associated with neurotransmitter receptors and their subunits. Major over-represented biological processes were social behavior, vocalization behavior, learning and memory. The enriched cellular component of the proteins encoded by the genes identified in this systematic review were the postsynaptic membrane and the cell junction.Among the biological processes that were examined, genes involved in synaptic integrity, neurotransmitter metabolism, and cell adhesion molecules were significantly involved in the development of autism." @default.
- W3207369947 created "2021-10-25" @default.
- W3207369947 creator A5031294228 @default.
- W3207369947 creator A5040446425 @default.
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- W3207369947 creator A5050385468 @default.
- W3207369947 creator A5054935351 @default.
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- W3207369947 creator A5091149308 @default.
- W3207369947 date "2021-10-09" @default.
- W3207369947 modified "2023-10-01" @default.
- W3207369947 title "A systematic review of common genetic variation and biological pathways in autism spectrum disorder" @default.
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