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- W3207375141 abstract "Background:Fluoxetine (FLU) is a prototype of SSRIs and a first line drug for the treatment ofdepression. Aim of the work:This study was planned todemonstrate the histological features of parsnervosa after chronic fluoxetine treatment and the possible therapeutic effect of adipose-derivedmesenchymal stem Cells.Material and Method: Thirty healthy male adult albino ratswere classifiedinto four groups. Control group(Group I) included fifteen rats. Fluoxetine treated (Group II) includedfive rats that received 24 mg/kg/day of fluoxetine dissolved in 1.0 ml of tap water once a day.Fluoxetine group treated with ADSCs (Group III)included five rats that received fluoxetine as group(II) for30 days then injected once by ADSCs at a dose of 1×106 cells/rat in the tail vein suspended in0.5ml of phosphate-buffered saline (PBS). Recovery group (Group IV) included five rats that receivedfluoxetine for 30 days then received no treatment till the end of the experiment. Samples from parsnervosa were processed for light,immunohistochemical, morphometrical and statistical analyses.Results: Fluoxetine treated group showed pituicytes with different shaped nuclei and pale orvacuolated cytoplasm. Acidophilic small Herring bodies were noticed. Administration of ADSCsgreatly improved microscopic appearance ofcellswhile, recovery group showed more or less similarhistological changes as Fluoxetine group. Conclusion: Fluoxetine induced various deleterious changeson the pars nervosa of albino rat. These changes were almost corrected by ADSCs treatment" @default.
- W3207375141 created "2021-10-25" @default.
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- W3207375141 date "2021-01-01" @default.
- W3207375141 modified "2023-09-24" @default.
- W3207375141 title "Therapeutic Efficacy of Adipose-Derived Mesenchymal Stem Cells after Chronic Fluoxetine Treatment on pars nervosa in adult albino rats (light and immunohistochemical study)" @default.
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