Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207382801> ?p ?o ?g. }
- W3207382801 abstract "A large population of people is affected by obesity (OB) and its associated type 2 diabetes mellitus(T2DM). There are currently no safe and long-lasting anti-OB/T2DM therapies. Clinical data and preclinical transplantation studies show that transplanting metabolically active brown adipose tissue (BAT) is a promising approach to prevent and treat OB and its associated metabolic and cardiovascular diseases. However, most transplantation studies used mouse BAT, and it is uncertain whether the therapeutic effect would be applied to human BAT since human and mouse BATs have distinct differences. Here, we report the fabrication of three-dimensional (3D) human brown adipose microtissues, their survival and safety, and their capability to improve glucose and insulin homeostasis and manage body weight gain in high-fat diet (HFD)-induced OB and diabetic mice." @default.
- W3207382801 created "2021-10-25" @default.
- W3207382801 creator A5008671228 @default.
- W3207382801 creator A5015232182 @default.
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- W3207382801 creator A5088891531 @default.
- W3207382801 creator A5089050011 @default.
- W3207382801 creator A5090941200 @default.
- W3207382801 date "2021-10-12" @default.
- W3207382801 modified "2023-09-24" @default.
- W3207382801 title "Engineered human brown adipocyte microtissues improved glucose and insulin homeostasis in high fat diet-induced obese and diabetic mice" @default.
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