FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207415501> ?p ?o ?g. }

• W3207415501 abstract "Oral cancer is often preceded by a mucosal lesion called an oral potentially malignant disorder (OPMD). Many plant-derived compounds are of value in medicine. The objectives of this study were to develop a soluble mucoadhesive film containing α-mangostin (α-MG), a compound extracted from the peel of mangosteen fruit, and determine its activities against oral cancer cells, against human papillomavirus type 16 (HPV-16) pseudovirus, and its anti-inflammatory properties.A soluble mucoadhesive film containing α-MG was prepared. Oral squamous carcinoma cell line (SCC25), murine macrophage cells (RAW264.7), and human gingival fibroblast cell line were cultured. Anticancer activity and viability of SCC25 cells in response to α-MG film solution were determined by MTT assay. HPV-16 pseudovirus was constructed and effects of the film solution on attachment and post-attachment steps of the infection were investigated. Anti-inflammatory activity was assessed by nitric oxide (NO) inhibition. Fibroblast cell migration was determined by in vitro scratch assay.The soluble α-MG film showed cytotoxic effects on SCC25 cells in concentration > 125 µg/ml with IC50 of 152.5 µg/ml. Antiviral activity against HPV-16 pseudovirus was observed at attachment step, but not at post-attachment step. The film also possessed a strong anti-inflammatory effect and promoted wound healing without cytotoxicity.Mucoadhesive film containing α-MG has a cytotoxic effect on oral squamous carcinoma cell line and an inhibitory effect on HPV-16 pseudovirus at attachment step. The α-MG film also shows a potent anti-inflammatory activity and enhances wound healing. Thus, the soluble α-MG film may have a potential role in treating oral cancer." @default.
• W3207415501 created "2021-10-25" @default.
• W3207415501 creator A5003489649 @default.
• W3207415501 creator A5004022454 @default.
• W3207415501 creator A5006391500 @default.
• W3207415501 creator A5009619918 @default.
• W3207415501 creator A5048344126 @default.
• W3207415501 creator A5050733688 @default.
• W3207415501 creator A5076889074 @default.
• W3207415501 creator A5091813615 @default.
• W3207415501 date "2021-10-10" @default.
• W3207415501 modified "2023-09-27" @default.
• W3207415501 title "Mucoadhesive film containing α-mangostin shows potential role in oral cancer treatment" @default.
• W3207415501 cites W1585242242 @default.
• W3207415501 cites W1963592300 @default.
• W3207415501 cites W1980588484 @default.
• W3207415501 cites W1987807963 @default.
• W3207415501 cites W2002423563 @default.
• W3207415501 cites W2046479988 @default.
• W3207415501 cites W2047799077 @default.
• W3207415501 cites W2049491375 @default.
• W3207415501 cites W2081425950 @default.
• W3207415501 cites W2084980412 @default.
• W3207415501 cites W2097229558 @default.
• W3207415501 cites W2099540110 @default.
• W3207415501 cites W2110187114 @default.
• W3207415501 cites W2128490578 @default.
• W3207415501 cites W2139172704 @default.
• W3207415501 cites W2143789052 @default.
• W3207415501 cites W2164217492 @default.
• W3207415501 cites W2165453779 @default.
• W3207415501 cites W2170552969 @default.
• W3207415501 cites W2291055813 @default.
• W3207415501 cites W2419293159 @default.
• W3207415501 cites W2463620414 @default.
• W3207415501 cites W2742812243 @default.
• W3207415501 cites W2753111208 @default.
• W3207415501 cites W2774476755 @default.
• W3207415501 cites W2797723772 @default.
• W3207415501 cites W2914912190 @default.
• W3207415501 cites W2973308638 @default.
• W3207415501 doi "https://doi.org/10.1186/s12903-021-01845-0" @default.
• W3207415501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8504111" @default.
• W3207415501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34629065" @default.
• W3207415501 hasPublicationYear "2021" @default.
• W3207415501 type Work @default.
• W3207415501 sameAs 3207415501 @default.
• W3207415501 citedByCount "2" @default.
• W3207415501 countsByYear W32074155012022 @default.
• W3207415501 countsByYear W32074155012023 @default.
• W3207415501 crossrefType "journal-article" @default.
• W3207415501 hasAuthorship W3207415501A5003489649 @default.
• W3207415501 hasAuthorship W3207415501A5004022454 @default.
• W3207415501 hasAuthorship W3207415501A5006391500 @default.
• W3207415501 hasAuthorship W3207415501A5009619918 @default.
• W3207415501 hasAuthorship W3207415501A5048344126 @default.
• W3207415501 hasAuthorship W3207415501A5050733688 @default.
• W3207415501 hasAuthorship W3207415501A5076889074 @default.
• W3207415501 hasAuthorship W3207415501A5091813615 @default.
• W3207415501 hasBestOaLocation W32074155011 @default.
• W3207415501 hasConcept C109316439 @default.
• W3207415501 hasConcept C121608353 @default.
• W3207415501 hasConcept C126322002 @default.
• W3207415501 hasConcept C1491633281 @default.
• W3207415501 hasConcept C154317977 @default.
• W3207415501 hasConcept C185592680 @default.
• W3207415501 hasConcept C202751555 @default.
• W3207415501 hasConcept C203014093 @default.
• W3207415501 hasConcept C2777752497 @default.
• W3207415501 hasConcept C2778005187 @default.
• W3207415501 hasConcept C2780269544 @default.
• W3207415501 hasConcept C2780381497 @default.
• W3207415501 hasConcept C2780783641 @default.
• W3207415501 hasConcept C502942594 @default.
• W3207415501 hasConcept C54355233 @default.
• W3207415501 hasConcept C55493867 @default.
• W3207415501 hasConcept C71924100 @default.
• W3207415501 hasConcept C81885089 @default.
• W3207415501 hasConcept C86803240 @default.
• W3207415501 hasConcept C98274493 @default.
• W3207415501 hasConceptScore W3207415501C109316439 @default.
• W3207415501 hasConceptScore W3207415501C121608353 @default.
• W3207415501 hasConceptScore W3207415501C126322002 @default.
• W3207415501 hasConceptScore W3207415501C1491633281 @default.
• W3207415501 hasConceptScore W3207415501C154317977 @default.
• W3207415501 hasConceptScore W3207415501C185592680 @default.
• W3207415501 hasConceptScore W3207415501C202751555 @default.
• W3207415501 hasConceptScore W3207415501C203014093 @default.
• W3207415501 hasConceptScore W3207415501C2777752497 @default.
• W3207415501 hasConceptScore W3207415501C2778005187 @default.
• W3207415501 hasConceptScore W3207415501C2780269544 @default.
• W3207415501 hasConceptScore W3207415501C2780381497 @default.
• W3207415501 hasConceptScore W3207415501C2780783641 @default.
• W3207415501 hasConceptScore W3207415501C502942594 @default.
• W3207415501 hasConceptScore W3207415501C54355233 @default.
• W3207415501 hasConceptScore W3207415501C55493867 @default.
• W3207415501 hasConceptScore W3207415501C71924100 @default.
• W3207415501 hasConceptScore W3207415501C81885089 @default.
• W3207415501 hasConceptScore W3207415501C86803240 @default.
• W3207415501 hasConceptScore W3207415501C98274493 @default.

• next