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- W3207422518 abstract "Cell therapy is on the precipice of a human health revolution where we will no longer be limited by therapeutic efficacy but instead by the ability to get therapies to patients. Therefore, there is a critical need to consider the logistics of scale and biomanufacturing, even during the discovery and proof-of-concept phases of development. We also need to approach these challenges through a lens unique to cell therapy, rather than constraining future innovation on historical success in tangential fields. Should we aim to directly mimic the elegant hierarchies of expansion and differentiation in the body? Can we decouple stem cell expansion and differentiation to rewire native systems and achieve other manufacturing constraints? Can we let the body take over some of the manufacturing burden? As there are likely many routes to a solution, the challenge of scalable manufacturing of stem cell therapies is prime for innovation by bioengineers." @default.
- W3207422518 created "2021-10-25" @default.
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- W3207422518 date "2021-10-01" @default.
- W3207422518 modified "2023-09-24" @default.
- W3207422518 title "Finding the volume dial in stem cell manufacturing: bioinspired and bioengineered approaches to scale up" @default.
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