Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207425769> ?p ?o ?g. }
- W3207425769 endingPage "180" @default.
- W3207425769 startingPage "155" @default.
- W3207425769 abstract "Parkinson’s disease (PD) is the second most common neurodegenerative disorder, with a documented significant increase in its prevalence in the past three decades. Both environmental and genetic factors contribute to the pathophysiology of this disorder. The diagnosis relies mainly on clinical findings, and currently, there is no reliable and trustworthy method of early identification of PD except for genetic testing limited to rare cases of monogenic forms of the disease. Current scientific research is focused on the identification of new diagnostic criteria and new disease biomarkers, allowing correct and timely diagnosis. Various types of potential PD biomarkers have been tested, including clinical, imaging, pathological, biochemical, and genetic, but none of them can be considered excellent or even satisfactory. However, several recent developments raise hope that early diagnosis of PD will be possible in the near future. The finding of reliable PD biomarkers may happen due to the successes in the field of neuroimaging, including positron emission tomography (PET), single-photon emission CT (SPECT), novel MRI techniques, as well as a result of the progress of new biochemical methods. Examples of these methods include aggregated α-synuclein measurements by real-time quaking-induced conversion (RT-QuIC), protein misfolding cyclic amplification (PMCA), and development of epigenetic-based biomarkers. Besides, a combination of biomarkers looks very promising to maximize their utility and ensure an accurate diagnosis of premotor or early-stage PD. Our goal here is to provide the reader with new developments in biomarkers suitable for early PD identification and to highlight the advantages and limitations of an existing individual biomarker and their combination." @default.
- W3207425769 created "2021-10-25" @default.
- W3207425769 creator A5057934058 @default.
- W3207425769 date "2021-10-16" @default.
- W3207425769 modified "2023-10-04" @default.
- W3207425769 title "Biomarkers in Parkinson’s Disease" @default.
- W3207425769 cites W1529674879 @default.
- W3207425769 cites W1555034521 @default.
- W3207425769 cites W1595314981 @default.
- W3207425769 cites W1837152578 @default.
- W3207425769 cites W1873640461 @default.
- W3207425769 cites W1934236512 @default.
- W3207425769 cites W1966289898 @default.
- W3207425769 cites W1974361709 @default.
- W3207425769 cites W1978098619 @default.
- W3207425769 cites W1982038512 @default.
- W3207425769 cites W1990050702 @default.
- W3207425769 cites W1990202749 @default.
- W3207425769 cites W1997992120 @default.
- W3207425769 cites W1999687346 @default.
- W3207425769 cites W2007086697 @default.
- W3207425769 cites W2024947273 @default.
- W3207425769 cites W2026676471 @default.
- W3207425769 cites W2028569211 @default.
- W3207425769 cites W2035553952 @default.
- W3207425769 cites W2044908785 @default.
- W3207425769 cites W2048505369 @default.
- W3207425769 cites W2050781983 @default.
- W3207425769 cites W2057139781 @default.
- W3207425769 cites W2060657561 @default.
- W3207425769 cites W2061543605 @default.
- W3207425769 cites W2068542905 @default.
- W3207425769 cites W2069360612 @default.
- W3207425769 cites W2069536617 @default.
- W3207425769 cites W2073449985 @default.
- W3207425769 cites W2078245222 @default.
- W3207425769 cites W2078781576 @default.
- W3207425769 cites W2086412028 @default.
- W3207425769 cites W2088463370 @default.
- W3207425769 cites W2096478757 @default.
- W3207425769 cites W2096916909 @default.
- W3207425769 cites W2098397252 @default.
- W3207425769 cites W2104758750 @default.
- W3207425769 cites W2104889897 @default.
- W3207425769 cites W2114655563 @default.
- W3207425769 cites W2123431154 @default.
- W3207425769 cites W2129229339 @default.
- W3207425769 cites W2131365154 @default.
- W3207425769 cites W2132511193 @default.
- W3207425769 cites W2137846828 @default.
- W3207425769 cites W2139281467 @default.
- W3207425769 cites W2141672954 @default.
- W3207425769 cites W2143505927 @default.
- W3207425769 cites W2147453648 @default.
- W3207425769 cites W2148397342 @default.
- W3207425769 cites W2150656456 @default.
- W3207425769 cites W2154737306 @default.
- W3207425769 cites W2155408421 @default.
- W3207425769 cites W2166600482 @default.
- W3207425769 cites W2178750505 @default.
- W3207425769 cites W2287601811 @default.
- W3207425769 cites W2292726316 @default.
- W3207425769 cites W2338776562 @default.
- W3207425769 cites W246561811 @default.
- W3207425769 cites W2512837190 @default.
- W3207425769 cites W2513452411 @default.
- W3207425769 cites W2530396506 @default.
- W3207425769 cites W2536910529 @default.
- W3207425769 cites W2550583173 @default.
- W3207425769 cites W2558041282 @default.
- W3207425769 cites W2598788731 @default.
- W3207425769 cites W2599538630 @default.
- W3207425769 cites W2620090474 @default.
- W3207425769 cites W2625007402 @default.
- W3207425769 cites W2735082643 @default.
- W3207425769 cites W2735677419 @default.
- W3207425769 cites W2747236831 @default.
- W3207425769 cites W2752557740 @default.
- W3207425769 cites W2761168960 @default.
- W3207425769 cites W2765530424 @default.
- W3207425769 cites W2777074421 @default.
- W3207425769 cites W2781107974 @default.
- W3207425769 cites W2788975760 @default.
- W3207425769 cites W2791928525 @default.
- W3207425769 cites W2804970493 @default.
- W3207425769 cites W2883509673 @default.
- W3207425769 cites W2884010473 @default.
- W3207425769 cites W2892006039 @default.
- W3207425769 cites W2899031631 @default.
- W3207425769 cites W2899461683 @default.
- W3207425769 cites W2901519529 @default.
- W3207425769 cites W2904216866 @default.
- W3207425769 cites W2904412904 @default.
- W3207425769 cites W2905240798 @default.
- W3207425769 cites W2905444535 @default.
- W3207425769 cites W2909323059 @default.
- W3207425769 cites W2917448366 @default.
- W3207425769 cites W2921058608 @default.