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• W3207445152 abstract "Human chorionic gonadotrophin (hCG) point-of-care testing (POCT) devices are designed to provide a result during a patient encounter to guide care at that time. Although their general performance is documented, these devices have not been verified or compared in the context of optimising pregnancy of unknown location (PUL) prediction modelling and thus patient care. The primary aim was to correlate POCT hCG with standard laboratory testing (SLT) results independently and when the ‘M6’ PUL risk prediction model is used, whilst assessing efficiency and psychological wellbeing. 406 prospective PUL were included between November 2018 and April 2021. hCG POCT values produced by the Abbott i-STAT 1 POCT system were compared with SLT results. This data was incorporated into the M6 model to stratify each PUL as high or low risk of clinical complications. SLT and POCT patient care pathways were timed and compared, and the hospital anxiety and depression scale (HADS) was utilised to assess psychological wellbeing. 508 POCT and SLT results were suitable for correlation. Mean discrepancy was 12.2% with a correlation coefficient of 0.96. Of the 113 PUL that had paired 0 and 48-hour hCG results from both POCT and SLT suitable for comparison using the M6 model, high-risk sensitivity was 100%, there was similar overestimation of risk for low-risk outcomes and M6 model risk predictions were almost identical. 1347 timings were recorded throughout the patient care pathway. POCT results required 12 minutes to process compared with 128 minutes for SLT (p<0.0001). Up to 39% PUL experience moderate to severe anxiety with SLT in the interim psychological analysis. HCG levels measured with POCT correlate well with laboratory values. The M6 model retains performance using hCG values derived from POCT, but the POCT device is limited to hCG levels < 2000IU/L. There is greater efficiency in using POCT to obtain hCG results and risk stratify using the M6 model allowing prompt documentation and discussion of findings with senior colleagues and patients. The psychological benefit of POCT in PUL is under investigation." @default.
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• W3207445152 date "2021-10-01" @default.
• W3207445152 modified "2023-09-26" @default.
• W3207445152 title "OC06.01: Point‐of‐care testing in pregnancy of unknown location outcome prediction" @default.
• W3207445152 doi "https://doi.org/10.1002/uog.23813" @default.
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