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- W3207445253 abstract "Abstract Objective We sought to define how sensory neurotransmitters substance P and calcitonin gene‐related peptide (CGRP) affect membrane potential of vascular smooth muscle and endothelium. Methods Microelectrodes recorded membrane potential of smooth muscle from pressurized mouse mesenteric arteries (diameter, ~150 µm) and in endothelial tubes. Results Resting potential was similar (~ −45 mV) for each cell layer. Substance P hyperpolarized smooth muscle and endothelium ~ −15 mV; smooth muscle hyperpolarization was abolished by endothelial disruption or NO synthase inhibition. Blocking K Ca channels (apamin + charybdotoxin) attenuated hyperpolarization in both cell types. CGRP hyperpolarized endothelium and smooth muscle ~ −30 mV; smooth muscle hyperpolarization was independent of endothelium. Blocking K Ca channels prevented hyperpolarization to CGRP in endothelium but not smooth muscle. Inhibiting K ATP channels with glibenclamide or genetic deletion of K IR 6.1 attenuated hyperpolarization in smooth muscle but not endothelium. Pinacidil (K ATP channel agonist) hyperpolarized smooth muscle more than endothelium (~ −35 vs. ~ −20 mV). Conclusions Calcitonin gene‐related peptide elicits greater hyperpolarization than substance P. Substance P hyperpolarizes both cell layers through K Ca channels and involves endothelium‐derived NO in smooth muscle. Endothelial hyperpolarization to CGRP requires K Ca channels, while K ATP channels mediate hyperpolarization in smooth muscle. Differential K + channel activation in smooth muscle and endothelium through sensory neurotransmission may selectively tune mesenteric blood flow." @default.
- W3207445253 created "2021-10-25" @default.
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- W3207445253 date "2021-10-21" @default.
- W3207445253 modified "2023-10-13" @default.
- W3207445253 title "Differential hyperpolarization to substance P and calcitonin gene‐related peptide in smooth muscle versus endothelium of mouse mesenteric artery" @default.
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- W3207445253 doi "https://doi.org/10.1111/micc.12733" @default.
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