Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207458081> ?p ?o ?g. }
- W3207458081 endingPage "2859" @default.
- W3207458081 startingPage "2859" @default.
- W3207458081 abstract "Pharmaceuticals, fundamental in therapy and the prevention of known pathologies, are responsible for environmental pollution. These substances, called “emerging contaminants,” are harmful to human health because they enter the environment in quantities exceeding the natural self-capacity purification of the ecosystems. Furthermore, wastewater treatment plants (WWTPs) cannot remove these substances, which can undergo chemical/biological transformations in the environment, thus forming by-products, sometimes more toxic than the parent molecules; successively, they move into rivers and could reach the drinking water supplies. All these phenomena represent a severe public health problem. Therefore, the Water Framework Directive by European Union imposed the monitoring of drugs’ levels in aqueous matrices. Every two years, the EU carefully updates the list of potential water pollutants, called the Watch List, including pharmaceuticals, to evaluate their risk on the aquatic environment. The last Commission Implementing Decision (EU 2018/840) comprises several substances of primary concern. In addition, the scientific community is giving particular attention to other pharmaceuticals not yet on the Watch list, whose markets are in growth; particularly, the Phosphodiesterase 5 (PDE-5) inhibitors used for the pharmaceutical treatment of erectile dysfunction (ED) in men. This review discusses the presence of PDE-5 inhibitors in environmental systems, their toxic effects, the different kinds of removal, and the analytical methods normally adopted for their detection. In addition, the study helps figure out the best possible strategy to tackle pharmaceutical pollution by using analytical and advanced diagnostic methods." @default.
- W3207458081 created "2021-10-25" @default.
- W3207458081 creator A5002426892 @default.
- W3207458081 creator A5009702122 @default.
- W3207458081 creator A5021720190 @default.
- W3207458081 creator A5032241728 @default.
- W3207458081 creator A5043708444 @default.
- W3207458081 creator A5053457402 @default.
- W3207458081 creator A5063057334 @default.
- W3207458081 creator A5075368860 @default.
- W3207458081 date "2021-10-13" @default.
- W3207458081 modified "2023-09-25" @default.
- W3207458081 title "Phosphodiesterase-5 (PDE-5) Inhibitors as Emergent Environmental Contaminants: Advanced Remediation and Analytical Methods" @default.
- W3207458081 cites W1503944835 @default.
- W3207458081 cites W1519507963 @default.
- W3207458081 cites W1558292706 @default.
- W3207458081 cites W1901498181 @default.
- W3207458081 cites W1917551306 @default.
- W3207458081 cites W1965222604 @default.
- W3207458081 cites W1967248416 @default.
- W3207458081 cites W1971646244 @default.
- W3207458081 cites W1973839076 @default.
- W3207458081 cites W1974904275 @default.
- W3207458081 cites W1975105908 @default.
- W3207458081 cites W1976568868 @default.
- W3207458081 cites W1985646920 @default.
- W3207458081 cites W1989240373 @default.
- W3207458081 cites W1994011397 @default.
- W3207458081 cites W1994221839 @default.
- W3207458081 cites W1994775237 @default.
- W3207458081 cites W1995089473 @default.
- W3207458081 cites W1997689428 @default.
- W3207458081 cites W1999884347 @default.
- W3207458081 cites W2001959648 @default.
- W3207458081 cites W2009989575 @default.
- W3207458081 cites W2011593270 @default.
- W3207458081 cites W2017274489 @default.
- W3207458081 cites W2020596867 @default.
- W3207458081 cites W2022002361 @default.
- W3207458081 cites W2029124536 @default.
- W3207458081 cites W2031430185 @default.
- W3207458081 cites W2031761993 @default.
- W3207458081 cites W2037766564 @default.
- W3207458081 cites W2038961111 @default.
- W3207458081 cites W2040674242 @default.
- W3207458081 cites W2040760655 @default.
- W3207458081 cites W2041766254 @default.
- W3207458081 cites W2046047167 @default.
- W3207458081 cites W2046699359 @default.
- W3207458081 cites W2046791050 @default.
- W3207458081 cites W2055650085 @default.
- W3207458081 cites W2058942354 @default.
- W3207458081 cites W2060440468 @default.
- W3207458081 cites W2062523819 @default.
- W3207458081 cites W2062723387 @default.
- W3207458081 cites W2071430420 @default.
- W3207458081 cites W2074807955 @default.
- W3207458081 cites W2074855027 @default.
- W3207458081 cites W2074958331 @default.
- W3207458081 cites W2077640736 @default.
- W3207458081 cites W2082168442 @default.
- W3207458081 cites W2085885436 @default.
- W3207458081 cites W2090289878 @default.
- W3207458081 cites W2092795123 @default.
- W3207458081 cites W2099671075 @default.
- W3207458081 cites W2108638835 @default.
- W3207458081 cites W2113862852 @default.
- W3207458081 cites W2123709921 @default.
- W3207458081 cites W2125627292 @default.
- W3207458081 cites W2145937475 @default.
- W3207458081 cites W2150075786 @default.
- W3207458081 cites W2157947374 @default.
- W3207458081 cites W2176401435 @default.
- W3207458081 cites W2191689802 @default.
- W3207458081 cites W2239837503 @default.
- W3207458081 cites W2281851425 @default.
- W3207458081 cites W2346041803 @default.
- W3207458081 cites W2372721341 @default.
- W3207458081 cites W2488620659 @default.
- W3207458081 cites W2515425046 @default.
- W3207458081 cites W2536006397 @default.
- W3207458081 cites W2576936252 @default.
- W3207458081 cites W2587268286 @default.
- W3207458081 cites W2605112885 @default.
- W3207458081 cites W2613257777 @default.
- W3207458081 cites W2743391370 @default.
- W3207458081 cites W2745936943 @default.
- W3207458081 cites W2765379772 @default.
- W3207458081 cites W2781055474 @default.
- W3207458081 cites W2792755267 @default.
- W3207458081 cites W2795384580 @default.
- W3207458081 cites W2795430086 @default.
- W3207458081 cites W2895370006 @default.
- W3207458081 cites W2898361938 @default.
- W3207458081 cites W2898409251 @default.
- W3207458081 cites W2911529139 @default.
- W3207458081 cites W2911827314 @default.
- W3207458081 cites W2969510435 @default.