Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207501232> ?p ?o ?g. }
- W3207501232 endingPage "26494" @default.
- W3207501232 startingPage "26489" @default.
- W3207501232 abstract "Abstract DNA‐protein cross‐links (DPCs) between DNA epigenetic mark 5‐formylC and lysine residues of histone proteins spontaneously form in human cells. Such conjugates are likely to influence chromatin structure and mediate DNA replication, transcription, and repair, but are challenging to study due to their reversible nature. Here we report the construction of site specific, hydrolytically stable DPCs between 5fdC in DNA and K4 of histone H3 and an investigation of their effects on DNA replication. Our approach employs oxime ligation, allowing for site‐specific conjugation of histones to DNA under physiological conditions. Primer extension experiments revealed that histone H3‐DNA crosslinks blocked DNA synthesis by hPol η polymerase, but were bypassed following proteolytic processing." @default.
- W3207501232 created "2021-10-25" @default.
- W3207501232 creator A5010428692 @default.
- W3207501232 creator A5018061374 @default.
- W3207501232 creator A5022400340 @default.
- W3207501232 creator A5030253904 @default.
- W3207501232 creator A5044102245 @default.
- W3207501232 creator A5061403041 @default.
- W3207501232 creator A5063458386 @default.
- W3207501232 creator A5068509910 @default.
- W3207501232 creator A5072557821 @default.
- W3207501232 creator A5078305812 @default.
- W3207501232 date "2021-11-16" @default.
- W3207501232 modified "2023-10-09" @default.
- W3207501232 title "Site‐Specific 5‐Formyl Cytosine Mediated DNA‐Histone Cross‐Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η" @default.
- W3207501232 cites W1489501428 @default.
- W3207501232 cites W1965220049 @default.
- W3207501232 cites W1967762868 @default.
- W3207501232 cites W1980745500 @default.
- W3207501232 cites W1983647569 @default.
- W3207501232 cites W1994590240 @default.
- W3207501232 cites W1997453048 @default.
- W3207501232 cites W1998977935 @default.
- W3207501232 cites W2005574849 @default.
- W3207501232 cites W2015786741 @default.
- W3207501232 cites W2019077508 @default.
- W3207501232 cites W2020815084 @default.
- W3207501232 cites W2034868296 @default.
- W3207501232 cites W2042344660 @default.
- W3207501232 cites W2085416172 @default.
- W3207501232 cites W2094249206 @default.
- W3207501232 cites W2112321284 @default.
- W3207501232 cites W2119933989 @default.
- W3207501232 cites W2124071121 @default.
- W3207501232 cites W2132099807 @default.
- W3207501232 cites W2332008572 @default.
- W3207501232 cites W2341980552 @default.
- W3207501232 cites W2414188270 @default.
- W3207501232 cites W2519158631 @default.
- W3207501232 cites W2543333792 @default.
- W3207501232 cites W2588973931 @default.
- W3207501232 cites W2594378117 @default.
- W3207501232 cites W2606495359 @default.
- W3207501232 cites W2731454206 @default.
- W3207501232 cites W2736809432 @default.
- W3207501232 cites W2752723776 @default.
- W3207501232 cites W2803731405 @default.
- W3207501232 cites W2805698278 @default.
- W3207501232 cites W2808383642 @default.
- W3207501232 cites W2895991294 @default.
- W3207501232 cites W2947930642 @default.
- W3207501232 cites W3000547412 @default.
- W3207501232 cites W3034535568 @default.
- W3207501232 cites W3041073132 @default.
- W3207501232 cites W3164420102 @default.
- W3207501232 cites W4205452706 @default.
- W3207501232 cites W4245448812 @default.
- W3207501232 cites W4255805403 @default.
- W3207501232 doi "https://doi.org/10.1002/anie.202109418" @default.
- W3207501232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34634172" @default.
- W3207501232 hasPublicationYear "2021" @default.
- W3207501232 type Work @default.
- W3207501232 sameAs 3207501232 @default.
- W3207501232 citedByCount "7" @default.
- W3207501232 countsByYear W32075012322022 @default.
- W3207501232 countsByYear W32075012322023 @default.
- W3207501232 crossrefType "journal-article" @default.
- W3207501232 hasAuthorship W3207501232A5010428692 @default.
- W3207501232 hasAuthorship W3207501232A5018061374 @default.
- W3207501232 hasAuthorship W3207501232A5022400340 @default.
- W3207501232 hasAuthorship W3207501232A5030253904 @default.
- W3207501232 hasAuthorship W3207501232A5044102245 @default.
- W3207501232 hasAuthorship W3207501232A5061403041 @default.
- W3207501232 hasAuthorship W3207501232A5063458386 @default.
- W3207501232 hasAuthorship W3207501232A5068509910 @default.
- W3207501232 hasAuthorship W3207501232A5072557821 @default.
- W3207501232 hasAuthorship W3207501232A5078305812 @default.
- W3207501232 hasBestOaLocation W32075012322 @default.
- W3207501232 hasConcept C104317684 @default.
- W3207501232 hasConcept C153911025 @default.
- W3207501232 hasConcept C156719811 @default.
- W3207501232 hasConcept C178790620 @default.
- W3207501232 hasConcept C185592680 @default.
- W3207501232 hasConcept C2756471 @default.
- W3207501232 hasConcept C2777563447 @default.
- W3207501232 hasConcept C31254050 @default.
- W3207501232 hasConcept C49105822 @default.
- W3207501232 hasConcept C552990157 @default.
- W3207501232 hasConcept C55493867 @default.
- W3207501232 hasConcept C64927066 @default.
- W3207501232 hasConcept C73573662 @default.
- W3207501232 hasConcept C82381507 @default.
- W3207501232 hasConcept C83640560 @default.
- W3207501232 hasConcept C86803240 @default.
- W3207501232 hasConcept C88354546 @default.
- W3207501232 hasConcept C95444343 @default.
- W3207501232 hasConceptScore W3207501232C104317684 @default.
- W3207501232 hasConceptScore W3207501232C153911025 @default.