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- W3207514624 abstract "Precocious movements are widely seen in embryos of various animal species. Whether such movements via proprioceptive feedback play instructive roles in motor development or are a mere reflection of activities in immature motor circuits is a long-standing question. Here we image the emerging motor activities in Drosophila embryos that lack proprioceptive feedback and show that proprioceptive experience is essential for the development of locomotor central pattern generators (CPGs). Downstream of proprioceptive inputs, we identify a pioneer premotor circuit composed of two pairs of segmental interneurons, whose gap-junctional transmission requires proprioceptive experience and plays a crucial role in CPG formation. The circuit autonomously generates rhythmic plateau potentials via IP3-mediated Ca2+ release from internal stores, which contribute to muscle contractions and hence produce proprioceptive feedback. Our findings demonstrate the importance of self-generated movements in instructing motor development and identify the cells, circuit, and physiology at the core of this proprioceptive feedback." @default.
- W3207514624 created "2021-10-25" @default.
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- W3207514624 date "2021-12-01" @default.
- W3207514624 modified "2023-10-16" @default.
- W3207514624 title "An electrically coupled pioneer circuit enables motor development via proprioceptive feedback in Drosophila embryos" @default.
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- W3207514624 cites W1968066792 @default.
- W3207514624 cites W1975012692 @default.
- W3207514624 cites W1976499757 @default.
- W3207514624 cites W1977060982 @default.
- W3207514624 cites W1977215035 @default.
- W3207514624 cites W1978862241 @default.
- W3207514624 cites W1981426699 @default.
- W3207514624 cites W1981762712 @default.
- W3207514624 cites W1986408320 @default.
- W3207514624 cites W1997778815 @default.
- W3207514624 cites W1997996755 @default.
- W3207514624 cites W2002708908 @default.
- W3207514624 cites W2002972805 @default.
- W3207514624 cites W2016749689 @default.
- W3207514624 cites W2022420377 @default.
- W3207514624 cites W2025812075 @default.
- W3207514624 cites W2027510518 @default.
- W3207514624 cites W2029088119 @default.
- W3207514624 cites W2034180599 @default.
- W3207514624 cites W2039728034 @default.
- W3207514624 cites W2041488220 @default.
- W3207514624 cites W2043596722 @default.
- W3207514624 cites W2050215536 @default.
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- W3207514624 cites W2055979678 @default.
- W3207514624 cites W2059608691 @default.
- W3207514624 cites W2059743066 @default.
- W3207514624 cites W2060087154 @default.
- W3207514624 cites W2061645562 @default.
- W3207514624 cites W2062777978 @default.
- W3207514624 cites W2064097709 @default.
- W3207514624 cites W2064215369 @default.
- W3207514624 cites W2066057252 @default.
- W3207514624 cites W2066188896 @default.
- W3207514624 cites W2067877248 @default.
- W3207514624 cites W2069280878 @default.
- W3207514624 cites W2069306062 @default.
- W3207514624 cites W2073210804 @default.
- W3207514624 cites W2074334096 @default.
- W3207514624 cites W2081102786 @default.
- W3207514624 cites W2081669905 @default.
- W3207514624 cites W2087543137 @default.
- W3207514624 cites W2093162791 @default.
- W3207514624 cites W2094442107 @default.
- W3207514624 cites W2104220712 @default.
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- W3207514624 cites W2108209263 @default.
- W3207514624 cites W2111591372 @default.
- W3207514624 cites W2113270338 @default.
- W3207514624 cites W2124140792 @default.
- W3207514624 cites W2124265878 @default.
- W3207514624 cites W2136465646 @default.
- W3207514624 cites W2136867476 @default.
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- W3207514624 cites W2157622411 @default.
- W3207514624 cites W2158297342 @default.
- W3207514624 cites W2158601315 @default.
- W3207514624 cites W2164833592 @default.
- W3207514624 cites W2166867937 @default.
- W3207514624 cites W2181199607 @default.
- W3207514624 cites W2184968222 @default.
- W3207514624 cites W2288653959 @default.
- W3207514624 cites W2421793514 @default.
- W3207514624 cites W2472629575 @default.
- W3207514624 cites W2577763879 @default.
- W3207514624 cites W2583381645 @default.
- W3207514624 cites W2737052624 @default.
- W3207514624 cites W2772180576 @default.
- W3207514624 cites W2795791164 @default.
- W3207514624 cites W2799077984 @default.
- W3207514624 cites W2885733168 @default.
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- W3207514624 doi "https://doi.org/10.1016/j.cub.2021.10.005" @default.
- W3207514624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34666002" @default.
- W3207514624 hasPublicationYear "2021" @default.
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