FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207522312> ?p ?o ?g. }

• W3207522312 abstract "Diverse sigma factors associate with the RNA polymerase (RNAP) core enzyme to initiate transcription of specific target genes in bacteria. σ54-Mediated transcription uses AAA+ activators that utilize their ATPase activity for transcription initiation. FleQ is a σ54-dependent master transcriptional regulator of flagellar genes in Pseudomonas aeruginosa. The ATPase activity of FleQ is regulated via a P-loop ATPase, FleN, through protein-protein interaction. We report a high-resolution crystal structure of the AAA+ domain of FleQ in complex with antiactivator FleN. The data reveal that FleN allosterically prevents ATP binding to FleQ. Furthermore, FleN remodels the region of FleQ essential for engagement with σ54 for transcription initiation. Disruption of the conserved protein-protein interface, by mutation, shows motility and transcription defects in vivo and multiflagellate phenotype. Our study provides a detailed mechanism used by monoflagellate bacteria to fine-tune the expression of flagellar genes to form and maintain a single flagellum." @default.
• W3207522312 created "2021-10-25" @default.
• W3207522312 creator A5021146851 @default.
• W3207522312 creator A5035541617 @default.
• W3207522312 creator A5037280953 @default.
• W3207522312 creator A5067388126 @default.
• W3207522312 creator A5071871018 @default.
• W3207522312 date "2021-10-22" @default.
• W3207522312 modified "2023-10-05" @default.
• W3207522312 title "The antiactivator FleN uses an allosteric mechanism to regulate σ ⁵⁴ -dependent expression of flagellar genes in <i>Pseudomonas aeruginosa</i>" @default.
• W3207522312 cites W1582203190 @default.
• W3207522312 cites W1603527036 @default.
• W3207522312 cites W1806679911 @default.
• W3207522312 cites W1878818450 @default.
• W3207522312 cites W1906539528 @default.
• W3207522312 cites W1986917571 @default.
• W3207522312 cites W2000114467 @default.
• W3207522312 cites W2018720646 @default.
• W3207522312 cites W2021091767 @default.
• W3207522312 cites W2037396322 @default.
• W3207522312 cites W2048205348 @default.
• W3207522312 cites W2049201314 @default.
• W3207522312 cites W2051133216 @default.
• W3207522312 cites W2052094781 @default.
• W3207522312 cites W2086869063 @default.
• W3207522312 cites W2091589285 @default.
• W3207522312 cites W2092227712 @default.
• W3207522312 cites W2095593044 @default.
• W3207522312 cites W2103503454 @default.
• W3207522312 cites W2103714813 @default.
• W3207522312 cites W2105618126 @default.
• W3207522312 cites W2114131567 @default.
• W3207522312 cites W2124103064 @default.
• W3207522312 cites W2135696727 @default.
• W3207522312 cites W2144081223 @default.
• W3207522312 cites W2146153980 @default.
• W3207522312 cites W2146287126 @default.
• W3207522312 cites W2147498477 @default.
• W3207522312 cites W2149979454 @default.
• W3207522312 cites W2154197653 @default.
• W3207522312 cites W2157378179 @default.
• W3207522312 cites W2164368007 @default.
• W3207522312 cites W2221987900 @default.
• W3207522312 cites W2412958199 @default.
• W3207522312 cites W2569383347 @default.
• W3207522312 cites W2793311671 @default.
• W3207522312 cites W2941803689 @default.
• W3207522312 cites W2952070597 @default.
• W3207522312 cites W4210675630 @default.
• W3207522312 doi "https://doi.org/10.1126/sciadv.abj1792" @default.
• W3207522312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8528422" @default.
• W3207522312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34669473" @default.
• W3207522312 hasPublicationYear "2021" @default.
• W3207522312 type Work @default.
• W3207522312 sameAs 3207522312 @default.
• W3207522312 citedByCount "12" @default.
• W3207522312 countsByYear W32075223122021 @default.
• W3207522312 countsByYear W32075223122022 @default.
• W3207522312 countsByYear W32075223122023 @default.
• W3207522312 crossrefType "journal-article" @default.
• W3207522312 hasAuthorship W3207522312A5021146851 @default.
• W3207522312 hasAuthorship W3207522312A5035541617 @default.
• W3207522312 hasAuthorship W3207522312A5037280953 @default.
• W3207522312 hasAuthorship W3207522312A5067388126 @default.
• W3207522312 hasAuthorship W3207522312A5071871018 @default.
• W3207522312 hasBestOaLocation W32075223122 @default.
• W3207522312 hasConcept C104317684 @default.
• W3207522312 hasConcept C115811362 @default.
• W3207522312 hasConcept C138885662 @default.
• W3207522312 hasConcept C166342909 @default.
• W3207522312 hasConcept C179926584 @default.
• W3207522312 hasConcept C181199279 @default.
• W3207522312 hasConcept C23265538 @default.
• W3207522312 hasConcept C26261996 @default.
• W3207522312 hasConcept C2776449523 @default.
• W3207522312 hasConcept C41895202 @default.
• W3207522312 hasConcept C47319516 @default.
• W3207522312 hasConcept C54355233 @default.
• W3207522312 hasConcept C55493867 @default.
• W3207522312 hasConcept C67705224 @default.
• W3207522312 hasConcept C86339819 @default.
• W3207522312 hasConcept C86803240 @default.
• W3207522312 hasConcept C95444343 @default.
• W3207522312 hasConceptScore W3207522312C104317684 @default.
• W3207522312 hasConceptScore W3207522312C115811362 @default.
• W3207522312 hasConceptScore W3207522312C138885662 @default.
• W3207522312 hasConceptScore W3207522312C166342909 @default.
• W3207522312 hasConceptScore W3207522312C179926584 @default.
• W3207522312 hasConceptScore W3207522312C181199279 @default.
• W3207522312 hasConceptScore W3207522312C23265538 @default.
• W3207522312 hasConceptScore W3207522312C26261996 @default.
• W3207522312 hasConceptScore W3207522312C2776449523 @default.
• W3207522312 hasConceptScore W3207522312C41895202 @default.
• W3207522312 hasConceptScore W3207522312C47319516 @default.
• W3207522312 hasConceptScore W3207522312C54355233 @default.
• W3207522312 hasConceptScore W3207522312C55493867 @default.
• W3207522312 hasConceptScore W3207522312C67705224 @default.
• W3207522312 hasConceptScore W3207522312C86339819 @default.
• W3207522312 hasConceptScore W3207522312C86803240 @default.
• W3207522312 hasConceptScore W3207522312C95444343 @default.

• next