Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207524650> ?p ?o ?g. }
- W3207524650 endingPage "695" @default.
- W3207524650 startingPage "695" @default.
- W3207524650 abstract "Metabolic flexibility is the ability of an organism to adapt its energy source based on nutrient availability and energy requirements. In humans, this ability has been linked to cardio-metabolic health and healthy aging. Genome-scale metabolic models have been employed to simulate metabolic flexibility by computing the Respiratory Quotient (RQ), which is defined as the ratio of carbon dioxide produced to oxygen consumed, and varies between values of 0.7 for pure fat metabolism and 1.0 for pure carbohydrate metabolism. While the nutritional determinants of metabolic flexibility are known, the role of low energy expenditure and sedentary behavior in the development of metabolic inflexibility is less studied. In this study, we present a new description of metabolic flexibility in genome-scale metabolic models which accounts for energy expenditure, and we study the interactions between physical activity and nutrition in a set of patient-derived models of skeletal muscle metabolism in older adults. The simulations show that fuel choice is sensitive to ATP consumption rate in all models tested. The ability to adapt fuel utilization to energy demands is an intrinsic property of the metabolic network." @default.
- W3207524650 created "2021-10-25" @default.
- W3207524650 creator A5038218119 @default.
- W3207524650 creator A5063543149 @default.
- W3207524650 creator A5083639021 @default.
- W3207524650 date "2021-10-12" @default.
- W3207524650 modified "2023-09-26" @default.
- W3207524650 title "Simulating Metabolic Flexibility in Low Energy Expenditure Conditions Using Genome-Scale Metabolic Models" @default.
- W3207524650 cites W1974756058 @default.
- W3207524650 cites W1974939683 @default.
- W3207524650 cites W2015454275 @default.
- W3207524650 cites W2016142529 @default.
- W3207524650 cites W2031367929 @default.
- W3207524650 cites W2048465561 @default.
- W3207524650 cites W2097995193 @default.
- W3207524650 cites W2099800850 @default.
- W3207524650 cites W2109354849 @default.
- W3207524650 cites W2126525177 @default.
- W3207524650 cites W2127262263 @default.
- W3207524650 cites W2141612278 @default.
- W3207524650 cites W2148601172 @default.
- W3207524650 cites W2160541874 @default.
- W3207524650 cites W2164122881 @default.
- W3207524650 cites W2168445785 @default.
- W3207524650 cites W2291465340 @default.
- W3207524650 cites W2418056440 @default.
- W3207524650 cites W2507936136 @default.
- W3207524650 cites W2523314419 @default.
- W3207524650 cites W2618971909 @default.
- W3207524650 cites W2750850399 @default.
- W3207524650 cites W2789128799 @default.
- W3207524650 cites W2800658350 @default.
- W3207524650 cites W2814705819 @default.
- W3207524650 cites W2949726389 @default.
- W3207524650 cites W2950749297 @default.
- W3207524650 cites W3047506701 @default.
- W3207524650 doi "https://doi.org/10.3390/metabo11100695" @default.
- W3207524650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8537358" @default.
- W3207524650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34677410" @default.
- W3207524650 hasPublicationYear "2021" @default.
- W3207524650 type Work @default.
- W3207524650 sameAs 3207524650 @default.
- W3207524650 citedByCount "1" @default.
- W3207524650 countsByYear W32075246502023 @default.
- W3207524650 crossrefType "journal-article" @default.
- W3207524650 hasAuthorship W3207524650A5038218119 @default.
- W3207524650 hasAuthorship W3207524650A5063543149 @default.
- W3207524650 hasAuthorship W3207524650A5083639021 @default.
- W3207524650 hasBestOaLocation W32075246501 @default.
- W3207524650 hasConcept C101810790 @default.
- W3207524650 hasConcept C105795698 @default.
- W3207524650 hasConcept C134018914 @default.
- W3207524650 hasConcept C192989942 @default.
- W3207524650 hasConcept C2780598303 @default.
- W3207524650 hasConcept C2986317502 @default.
- W3207524650 hasConcept C2988147884 @default.
- W3207524650 hasConcept C2992768293 @default.
- W3207524650 hasConcept C33923547 @default.
- W3207524650 hasConcept C55493867 @default.
- W3207524650 hasConcept C60644358 @default.
- W3207524650 hasConcept C62231903 @default.
- W3207524650 hasConcept C86803240 @default.
- W3207524650 hasConcept C98488077 @default.
- W3207524650 hasConceptScore W3207524650C101810790 @default.
- W3207524650 hasConceptScore W3207524650C105795698 @default.
- W3207524650 hasConceptScore W3207524650C134018914 @default.
- W3207524650 hasConceptScore W3207524650C192989942 @default.
- W3207524650 hasConceptScore W3207524650C2780598303 @default.
- W3207524650 hasConceptScore W3207524650C2986317502 @default.
- W3207524650 hasConceptScore W3207524650C2988147884 @default.
- W3207524650 hasConceptScore W3207524650C2992768293 @default.
- W3207524650 hasConceptScore W3207524650C33923547 @default.
- W3207524650 hasConceptScore W3207524650C55493867 @default.
- W3207524650 hasConceptScore W3207524650C60644358 @default.
- W3207524650 hasConceptScore W3207524650C62231903 @default.
- W3207524650 hasConceptScore W3207524650C86803240 @default.
- W3207524650 hasConceptScore W3207524650C98488077 @default.
- W3207524650 hasFunder F4320332999 @default.
- W3207524650 hasIssue "10" @default.
- W3207524650 hasLocation W32075246501 @default.
- W3207524650 hasLocation W32075246502 @default.
- W3207524650 hasLocation W32075246503 @default.
- W3207524650 hasLocation W32075246504 @default.
- W3207524650 hasLocation W32075246505 @default.
- W3207524650 hasLocation W32075246506 @default.
- W3207524650 hasOpenAccess W3207524650 @default.
- W3207524650 hasPrimaryLocation W32075246501 @default.
- W3207524650 hasRelatedWork W2031771376 @default.
- W3207524650 hasRelatedWork W2037085403 @default.
- W3207524650 hasRelatedWork W2037621520 @default.
- W3207524650 hasRelatedWork W2097273600 @default.
- W3207524650 hasRelatedWork W2131672077 @default.
- W3207524650 hasRelatedWork W2298784219 @default.
- W3207524650 hasRelatedWork W2409228498 @default.
- W3207524650 hasRelatedWork W3164254441 @default.
- W3207524650 hasRelatedWork W3207524650 @default.
- W3207524650 hasRelatedWork W59975003 @default.
- W3207524650 hasVolume "11" @default.