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• W3207527571 endingPage "065028" @default.
• W3207527571 startingPage "065028" @default.
• W3207527571 abstract "Collagen and chitosan are two different kinds of natural biodegradable polymers commonly used in the regeneration of bone defects. Mesoporous bioactive glass (MBG) is a type of favorable bone filler which can effectively constitute an enlarged microenvironment to facilitate an exchange of important factors between the cells and scaffolds. Here we prepared a collagen-chitosan-MBG (C-C-MBG) scaffold which displayed significantly increased proliferation, differentiation and mineralization in bone mesenchymal stem cells (BMSCs). Additionally, we found that the scaffold can stimulate extra-cellular signal regulated kinase 1/2 (Erk1/2) activated Runx2 pathway, which is the predominant signaling pathway involved in osteoblast differentiation. Consistently, we observed that the scaffold can markedly enhance the expression ofType I collagen, Osteopontin(Opn), andRunx2, which are important osteoblastic marker genes implicated in the process of osteoblast differentiation. Therefore, we conclude that the composite scaffold can significantly promote the differentiation of BMSCs into osteoblasts by activating Erk1/2-Runx2 pathway. Our finding thereby implies that the C-C-MBG scaffold can possibly act as a potential biomaterial in the bone regeneration." @default.
• W3207527571 created "2021-10-25" @default.
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• W3207527571 date "2021-11-01" @default.
• W3207527571 modified "2023-09-26" @default.
• W3207527571 title "Design of novel functionalized collagen-chitosan-MBG scaffolds for enhancing osteoblast differentiation in BMSCs" @default.
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• W3207527571 doi "https://doi.org/10.1088/1748-605x/ac3146" @default.
• W3207527571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34670204" @default.
• W3207527571 hasPublicationYear "2021" @default.
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