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• W3207535810 startingPage "5189" @default.
• W3207535810 abstract "The detailed mechanisms of Epstein-Barr virus (EBV) infection in the initiation and progression of EBV-associated malignancies are not yet completely understood. During the last years, new insights into the mechanisms of malignant transformation of EBV-infected cells including somatic mutations and epigenetic modifications, their impact on the microenvironment and resulting unique immune signatures related to immune system functional status and immune escape strategies have been reported. In this context, there exists increasing evidence that EBV-infected tumor cells can influence the tumor microenvironment to their own benefit by establishing an immune-suppressive surrounding. The identified mechanisms include EBV gene integration and latent expression of EBV-infection-triggered cytokines by tumor and/or bystander cells, e.g., cancer-associated fibroblasts with effects on the composition and spatial distribution of the immune cell subpopulations next to the infected cells, stroma constituents and extracellular vesicles. This review summarizes (i) the typical stages of the viral life cycle and EBV-associated transformation, (ii) strategies to detect EBV genome and activity and to differentiate various latency types, (iii) the role of the tumor microenvironment in EBV-associated malignancies, (iv) the different immune escape mechanisms and (v) their clinical relevance. This gained information will enhance the development of therapies against EBV-mediated diseases to improve patient outcome." @default.
• W3207535810 created "2021-10-25" @default.
• W3207535810 creator A5009769102 @default.
• W3207535810 creator A5018687596 @default.
• W3207535810 creator A5029462216 @default.
• W3207535810 creator A5035583924 @default.
• W3207535810 creator A5063231601 @default.
• W3207535810 date "2021-10-16" @default.
• W3207535810 modified "2023-10-07" @default.
• W3207535810 title "Epstein–Barr Virus—Associated Malignancies and Immune Escape: The Role of the Tumor Microenvironment and Tumor Cell Evasion Strategies" @default.
• W3207535810 cites W134119395 @default.
• W3207535810 cites W1487223965 @default.
• W3207535810 cites W1492993345 @default.
• W3207535810 cites W1505583194 @default.
• W3207535810 cites W1535663350 @default.
• W3207535810 cites W1545631997 @default.
• W3207535810 cites W1578854334 @default.
• W3207535810 cites W1595961517 @default.
• W3207535810 cites W1605908963 @default.
• W3207535810 cites W1634084408 @default.
• W3207535810 cites W1636660170 @default.
• W3207535810 cites W1879257657 @default.
• W3207535810 cites W1883897672 @default.
• W3207535810 cites W1887290302 @default.
• W3207535810 cites W1913508491 @default.
• W3207535810 cites W1946498671 @default.
• W3207535810 cites W1964730223 @default.
• W3207535810 cites W1965863550 @default.
• W3207535810 cites W1966948366 @default.
• W3207535810 cites W1970149418 @default.
• W3207535810 cites W1970199385 @default.
• W3207535810 cites W1972078736 @default.
• W3207535810 cites W1972574193 @default.
• W3207535810 cites W1973470288 @default.
• W3207535810 cites W1974954833 @default.
• W3207535810 cites W1976687360 @default.
• W3207535810 cites W1978505174 @default.
• W3207535810 cites W1984710154 @default.
• W3207535810 cites W1985074330 @default.
• W3207535810 cites W1988209525 @default.
• W3207535810 cites W1988802964 @default.
• W3207535810 cites W1990440768 @default.
• W3207535810 cites W1990776313 @default.
• W3207535810 cites W1991226842 @default.
• W3207535810 cites W1992599190 @default.
• W3207535810 cites W1992696389 @default.
• W3207535810 cites W1992908727 @default.
• W3207535810 cites W1993180746 @default.
• W3207535810 cites W1993349395 @default.
• W3207535810 cites W1994903218 @default.
• W3207535810 cites W1996087599 @default.
• W3207535810 cites W1996127398 @default.
• W3207535810 cites W2003045938 @default.
• W3207535810 cites W2003939651 @default.
• W3207535810 cites W2005049291 @default.
• W3207535810 cites W2005569156 @default.
• W3207535810 cites W2008210462 @default.
• W3207535810 cites W2009173868 @default.
• W3207535810 cites W2009439409 @default.
• W3207535810 cites W2010845626 @default.
• W3207535810 cites W2015150577 @default.
• W3207535810 cites W2015270653 @default.
• W3207535810 cites W2019628586 @default.
• W3207535810 cites W2019916283 @default.
• W3207535810 cites W2021743722 @default.
• W3207535810 cites W2026626552 @default.
• W3207535810 cites W2032880597 @default.
• W3207535810 cites W2035098923 @default.
• W3207535810 cites W2036320218 @default.
• W3207535810 cites W2037105572 @default.
• W3207535810 cites W2038966816 @default.
• W3207535810 cites W2041551123 @default.
• W3207535810 cites W2045585289 @default.
• W3207535810 cites W2048737737 @default.
• W3207535810 cites W2049317749 @default.
• W3207535810 cites W2049591063 @default.
• W3207535810 cites W2050267474 @default.
• W3207535810 cites W2052439308 @default.
• W3207535810 cites W2053108666 @default.
• W3207535810 cites W2053631267 @default.
• W3207535810 cites W2053941126 @default.
• W3207535810 cites W2054817748 @default.
• W3207535810 cites W2054961298 @default.
• W3207535810 cites W2055039494 @default.
• W3207535810 cites W2058787177 @default.
• W3207535810 cites W2059073003 @default.
• W3207535810 cites W2059316119 @default.
• W3207535810 cites W2061612690 @default.
• W3207535810 cites W2063452120 @default.
• W3207535810 cites W2065433208 @default.
• W3207535810 cites W2067736783 @default.
• W3207535810 cites W2068994108 @default.
• W3207535810 cites W2072602437 @default.
• W3207535810 cites W2072646319 @default.
• W3207535810 cites W2073631928 @default.
• W3207535810 cites W2076166694 @default.
• W3207535810 cites W2076271153 @default.
• W3207535810 cites W2076930004 @default.

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