Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207536181> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3207536181 abstract "Background: Extracellular vesicles are membrane vesicles that are released into the extracellular environment and accumulate in the circulation in vascular disease. We aimed to quantify circulating extracellular vesicles in pregnant women with type 1 diabetes and to examine associations between extracellular vesicle levels, continuous glucose measures, and pregnancy outcomes. Methods: We used plasma samples from the Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial study and quantified circulating extracellular vesicles by flow cytometry (n = 163). Relationships with clinical variables were assessed by repeated measures correlation. Logistic regression was used to assess associations between elevated extracellular vesicle levels and pregnancy outcomes. Results: Platelet extracellular vesicle levels were inversely associated with glucose time above range and glycaemic variability measures (P < 0.05). A weak positive association was observed between endothelial extracellular vesicles and mean amplitude of glycemic excursion (P < 0.05). In a univariate logistic regression model, high baseline endothelial extracellular vesicles was associated with increased risk of neonatal intensive care unit (NICU) admission (OR: 2.06, 1.03–4.10), and respiratory distress requiring ventilation (OR: 4.98, 1.04–23.92). After adjusting for HbA1c and blood pressure the relationship for NICU admission persisted and an association with hyperbilirubinemia was seen (OR: 2.56, 1.10–5.94). Elevated platelet extracellular vesicles were associated with an increased risk of NICU admission (OR: 2.18, 1.04–4.57), and hyperbilirubinemia (OR: 2.61, 1.11–6.12) after adjusting for HbA1c and blood pressure. Conclusions: High levels of extracellular vesicles in early pregnancy were associated with adverse neonatal outcomes. Assessment of extracellular vesicles may represent a novel approach to personalized care in type 1 diabetes pregnancy." @default.
- W3207536181 created "2021-10-25" @default.
- W3207536181 creator A5011981202 @default.
- W3207536181 creator A5027214954 @default.
- W3207536181 creator A5029308902 @default.
- W3207536181 creator A5031195718 @default.
- W3207536181 creator A5091462313 @default.
- W3207536181 date "2021-09-06" @default.
- W3207536181 modified "2023-09-24" @default.
- W3207536181 title "Circulating extracellular vesicles during pregnancy in women with type 1 diabetes: a secondary analysis of the CONCEPTT trial." @default.
- W3207536181 hasPublicationYear "2021" @default.
- W3207536181 type Work @default.
- W3207536181 sameAs 3207536181 @default.
- W3207536181 citedByCount "0" @default.
- W3207536181 crossrefType "journal-article" @default.
- W3207536181 hasAuthorship W3207536181A5011981202 @default.
- W3207536181 hasAuthorship W3207536181A5027214954 @default.
- W3207536181 hasAuthorship W3207536181A5029308902 @default.
- W3207536181 hasAuthorship W3207536181A5031195718 @default.
- W3207536181 hasAuthorship W3207536181A5091462313 @default.
- W3207536181 hasConcept C104317684 @default.
- W3207536181 hasConcept C126322002 @default.
- W3207536181 hasConcept C130316041 @default.
- W3207536181 hasConcept C134018914 @default.
- W3207536181 hasConcept C145059251 @default.
- W3207536181 hasConcept C20518536 @default.
- W3207536181 hasConcept C2113261 @default.
- W3207536181 hasConcept C2779234561 @default.
- W3207536181 hasConcept C2781232474 @default.
- W3207536181 hasConcept C28406088 @default.
- W3207536181 hasConcept C2908689518 @default.
- W3207536181 hasConcept C2992929900 @default.
- W3207536181 hasConcept C41625074 @default.
- W3207536181 hasConcept C54355233 @default.
- W3207536181 hasConcept C55493867 @default.
- W3207536181 hasConcept C555293320 @default.
- W3207536181 hasConcept C71924100 @default.
- W3207536181 hasConcept C86803240 @default.
- W3207536181 hasConcept C95444343 @default.
- W3207536181 hasConceptScore W3207536181C104317684 @default.
- W3207536181 hasConceptScore W3207536181C126322002 @default.
- W3207536181 hasConceptScore W3207536181C130316041 @default.
- W3207536181 hasConceptScore W3207536181C134018914 @default.
- W3207536181 hasConceptScore W3207536181C145059251 @default.
- W3207536181 hasConceptScore W3207536181C20518536 @default.
- W3207536181 hasConceptScore W3207536181C2113261 @default.
- W3207536181 hasConceptScore W3207536181C2779234561 @default.
- W3207536181 hasConceptScore W3207536181C2781232474 @default.
- W3207536181 hasConceptScore W3207536181C28406088 @default.
- W3207536181 hasConceptScore W3207536181C2908689518 @default.
- W3207536181 hasConceptScore W3207536181C2992929900 @default.
- W3207536181 hasConceptScore W3207536181C41625074 @default.
- W3207536181 hasConceptScore W3207536181C54355233 @default.
- W3207536181 hasConceptScore W3207536181C55493867 @default.
- W3207536181 hasConceptScore W3207536181C555293320 @default.
- W3207536181 hasConceptScore W3207536181C71924100 @default.
- W3207536181 hasConceptScore W3207536181C86803240 @default.
- W3207536181 hasConceptScore W3207536181C95444343 @default.
- W3207536181 hasLocation W32075361811 @default.
- W3207536181 hasOpenAccess W3207536181 @default.
- W3207536181 hasPrimaryLocation W32075361811 @default.
- W3207536181 hasRelatedWork W2007658441 @default.
- W3207536181 hasRelatedWork W2034863650 @default.
- W3207536181 hasRelatedWork W2076722876 @default.
- W3207536181 hasRelatedWork W2097541951 @default.
- W3207536181 hasRelatedWork W2099717941 @default.
- W3207536181 hasRelatedWork W2107062695 @default.
- W3207536181 hasRelatedWork W2277497663 @default.
- W3207536181 hasRelatedWork W2329651390 @default.
- W3207536181 hasRelatedWork W2382448505 @default.
- W3207536181 hasRelatedWork W2387634581 @default.
- W3207536181 hasRelatedWork W2755133942 @default.
- W3207536181 hasRelatedWork W2765880437 @default.
- W3207536181 hasRelatedWork W2796539606 @default.
- W3207536181 hasRelatedWork W2913691982 @default.
- W3207536181 hasRelatedWork W2940541419 @default.
- W3207536181 hasRelatedWork W3029032246 @default.
- W3207536181 hasRelatedWork W3044941922 @default.
- W3207536181 hasRelatedWork W3114531865 @default.
- W3207536181 hasRelatedWork W3198017577 @default.
- W3207536181 hasRelatedWork W2186145956 @default.
- W3207536181 isParatext "false" @default.
- W3207536181 isRetracted "false" @default.
- W3207536181 magId "3207536181" @default.
- W3207536181 workType "article" @default.