FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207538191> ?p ?o ?g. }

• W3207538191 endingPage "1615" @default.
• W3207538191 startingPage "1615" @default.
• W3207538191 abstract "The wastewater from the distillation of rose oils is discharged directly into the soil because it has a limited potential for future applications. The aim of the present study was to determine in vitro the chromatographic profile, redox-modulating capacity, and antineoplastic activity of wastewater obtained by distillation of essential oils from the Bulgarian Rosa alba L., Rosa damascena Mill., Rosa gallica L., and Rosa centifolia L. We applied UHPLC-HRMS for chromatographic analysis of rose wastewaters, studied their metal-chelating and Fe(III)-reducing ability, and performed MTT assay for the evaluation of cytotoxic potential against three tumorigenic (HEPG2-hepatocellular adenocarcinoma, A-375-malignant melanoma, A-431-non-melanoma epidermoid squamous skin carcinoma) and one non-tumorigenic human cell lines (HaCaT-immortalized keratinocytes). The median inhibitory concentrations (IC50) were calculated with nonlinear modeling using the MAPLE® platform. The potential of the wastewaters to induce apoptosis was also examined. Mono-, di-, and acylated glycosides of quercetin and kaempferol, ellagic acid and its derivatives as main chemical components, and gallic acid and its derivatives-such as catechin and epicatechin-were identified. The redox-modulating capacity of the samples (TPTZ test) showed that all four wastewaters exhibited the properties of excellent heavy metal cleaners, but did not exert very strong cytotoxic effects. The lowest IC50 rate was provided in wastewater from R. centifolia (34-35 µg/mL of gallic acid equivalents after a 72 h period for all cell lines). At 24 and 48 hours, the most resistant cell line was HEPG2, followed by HaCaT. After 72 h of exposure, the IC50 values were similar for tumor and normal cells. Still, R. damascena had a selectivity index over 2.0 regarding A-431 non-melanoma skin cancer cells, showing a good toxicological safety profile in addition to moderate activity-IC50 of 35 µg/mL polyphenols. The obtained results related to wastewaters acquired after the distillation of essential oils from the Bulgarian R. alba, R. damascena, R. gallica, and R. centifolia direct our attention to further studies for in-depth elucidation of their application as detoxifying agents under oxidative damage conditions in other experimental datasets." @default.
• W3207538191 created "2021-10-25" @default.
• W3207538191 creator A5023839421 @default.
• W3207538191 creator A5024227405 @default.
• W3207538191 creator A5046068719 @default.
• W3207538191 creator A5049661095 @default.
• W3207538191 creator A5053719188 @default.
• W3207538191 creator A5053848036 @default.
• W3207538191 creator A5065309317 @default.
• W3207538191 creator A5070723409 @default.
• W3207538191 creator A5080012319 @default.
• W3207538191 date "2021-10-14" @default.
• W3207538191 modified "2023-10-12" @default.
• W3207538191 title "Redox-Modulating Capacity and Antineoplastic Activity of Wastewater Obtained from the Distillation of the Essential Oils of Four Bulgarian Oil-Bearing Roses" @default.
• W3207538191 cites W1745634660 @default.
• W3207538191 cites W1917220394 @default.
• W3207538191 cites W1965877011 @default.
• W3207538191 cites W1975423279 @default.
• W3207538191 cites W1975617209 @default.
• W3207538191 cites W1981344570 @default.
• W3207538191 cites W1981577290 @default.
• W3207538191 cites W1985693750 @default.
• W3207538191 cites W1986961578 @default.
• W3207538191 cites W1989226899 @default.
• W3207538191 cites W1991931599 @default.
• W3207538191 cites W1992544322 @default.
• W3207538191 cites W1996038905 @default.
• W3207538191 cites W1997183854 @default.
• W3207538191 cites W2002421430 @default.
• W3207538191 cites W2002490399 @default.
• W3207538191 cites W2004684106 @default.
• W3207538191 cites W2005315503 @default.
• W3207538191 cites W2007636933 @default.
• W3207538191 cites W2013194529 @default.
• W3207538191 cites W2018919826 @default.
• W3207538191 cites W2022652364 @default.
• W3207538191 cites W2029442922 @default.
• W3207538191 cites W2033007699 @default.
• W3207538191 cites W2042438338 @default.
• W3207538191 cites W2049102610 @default.
• W3207538191 cites W2050102962 @default.
• W3207538191 cites W2050923875 @default.
• W3207538191 cites W2053849298 @default.
• W3207538191 cites W2056092147 @default.
• W3207538191 cites W2056096759 @default.
• W3207538191 cites W2057088218 @default.
• W3207538191 cites W2060145371 @default.
• W3207538191 cites W2067398960 @default.
• W3207538191 cites W2070087431 @default.
• W3207538191 cites W2071866695 @default.
• W3207538191 cites W2072348601 @default.
• W3207538191 cites W2074635237 @default.
• W3207538191 cites W2076649973 @default.
• W3207538191 cites W2077945404 @default.
• W3207538191 cites W2085748209 @default.
• W3207538191 cites W2087514841 @default.
• W3207538191 cites W2094700166 @default.
• W3207538191 cites W2106195907 @default.
• W3207538191 cites W2106357931 @default.
• W3207538191 cites W2114138419 @default.
• W3207538191 cites W2123986234 @default.
• W3207538191 cites W2127553277 @default.
• W3207538191 cites W2141223977 @default.
• W3207538191 cites W2141239032 @default.
• W3207538191 cites W2145947053 @default.
• W3207538191 cites W2165292984 @default.
• W3207538191 cites W2167282521 @default.
• W3207538191 cites W2214882140 @default.
• W3207538191 cites W2315977067 @default.
• W3207538191 cites W2340886654 @default.
• W3207538191 cites W2412141617 @default.
• W3207538191 cites W2460134072 @default.
• W3207538191 cites W2518642608 @default.
• W3207538191 cites W2564161723 @default.
• W3207538191 cites W2564505095 @default.
• W3207538191 cites W2597266196 @default.
• W3207538191 cites W2606552568 @default.
• W3207538191 cites W2739943232 @default.
• W3207538191 cites W2745238358 @default.
• W3207538191 cites W2762109701 @default.
• W3207538191 cites W2766411707 @default.
• W3207538191 cites W2769622412 @default.
• W3207538191 cites W2770531014 @default.
• W3207538191 cites W2773416847 @default.
• W3207538191 cites W2784323226 @default.
• W3207538191 cites W2789783934 @default.
• W3207538191 cites W2803189841 @default.
• W3207538191 cites W2808302156 @default.
• W3207538191 cites W2884245587 @default.
• W3207538191 cites W2901151836 @default.
• W3207538191 cites W2912271344 @default.
• W3207538191 cites W2941496718 @default.
• W3207538191 cites W2950459932 @default.
• W3207538191 cites W2953806434 @default.
• W3207538191 cites W2965617946 @default.
• W3207538191 cites W2966176956 @default.
• W3207538191 cites W2971337026 @default.
• W3207538191 cites W2971594909 @default.

• next