FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207541583> ?p ?o ?g. }

• W3207541583 endingPage "42" @default.
• W3207541583 startingPage "31" @default.
• W3207541583 abstract "Hepatosteatosis, defined as excessive intrahepatic lipid accumulation, represents the first step of NAFLD. When combined with additional cellular stress, this benign status progresses to local and systemic pathological conditions such as NASH and insulin resistance. However, the molecular events directly caused by hepatic lipid build-up, in terms of its impact on liver biology and peripheral organs, remain unclear. Carnitine palmitoyltransferase 1A (CPT1A) is the rate limiting enzyme for long chain fatty acid beta-oxidation in the liver. Here we utilise hepatocyte-specific Cpt1a knockout (LKO) mice to investigate the physiological consequences of abolishing hepatic long chain fatty acid metabolism.Compared to the wild-type (WT) littermates, high fat diet (HFD)-fed LKO mice displayed more severe hepatosteatosis but were otherwise protected against diet-induced weight gain, insulin resistance, hepatic ER stress, inflammation and damage. Interestingly, increased energy expenditure was observed in LKO mice, accompanied by enhanced adipose tissue browning. RNAseq analysis revealed that the peroxisome proliferator activator alpha (PPARα)- fibroblast growth factor 21 (FGF21) axis was activated in liver of LKO mice. Importantly, antibody-mediated neutralization of FGF21 abolished the healthier metabolic phenotype and adipose browning in LKO mice, indicating that the elevation of FGF21 contributes to the improved liver pathology and adipose browning in HFD-treated LKO mice.Liver with deficient CPT1A expression adopts a healthy steatotic status that protects against HFD-evoked liver damage and potentiates adipose browning in an FGF21-dependent manner. Inhibition of hepatic CPT1A may serve as a viable strategy for the treatment of obesity and NAFLD." @default.
• W3207541583 created "2021-10-25" @default.
• W3207541583 creator A5001712204 @default.
• W3207541583 creator A5004975012 @default.
• W3207541583 creator A5005035675 @default.
• W3207541583 creator A5012131365 @default.
• W3207541583 creator A5013368285 @default.
• W3207541583 creator A5017941291 @default.
• W3207541583 creator A5022808077 @default.
• W3207541583 creator A5024153892 @default.
• W3207541583 creator A5024887366 @default.
• W3207541583 creator A5025869715 @default.
• W3207541583 creator A5025944032 @default.
• W3207541583 creator A5029784389 @default.
• W3207541583 creator A5033341142 @default.
• W3207541583 creator A5038746020 @default.
• W3207541583 creator A5062928937 @default.
• W3207541583 creator A5063307072 @default.
• W3207541583 creator A5066657162 @default.
• W3207541583 creator A5068420759 @default.
• W3207541583 creator A5069904410 @default.
• W3207541583 creator A5070188197 @default.
• W3207541583 date "2021-10-21" @default.
• W3207541583 modified "2023-10-16" @default.
• W3207541583 title "Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice" @default.
• W3207541583 cites W1501655398 @default.
• W3207541583 cites W1601325022 @default.
• W3207541583 cites W1839197698 @default.
• W3207541583 cites W1986038576 @default.
• W3207541583 cites W1986876315 @default.
• W3207541583 cites W1990034097 @default.
• W3207541583 cites W2002349285 @default.
• W3207541583 cites W2003910366 @default.
• W3207541583 cites W2006024610 @default.
• W3207541583 cites W2026241394 @default.
• W3207541583 cites W2030901818 @default.
• W3207541583 cites W2031573979 @default.
• W3207541583 cites W2048578282 @default.
• W3207541583 cites W2059216277 @default.
• W3207541583 cites W2075349430 @default.
• W3207541583 cites W2089198803 @default.
• W3207541583 cites W2092412521 @default.
• W3207541583 cites W2094507651 @default.
• W3207541583 cites W2097080554 @default.
• W3207541583 cites W2099656577 @default.
• W3207541583 cites W2114650931 @default.
• W3207541583 cites W2132596222 @default.
• W3207541583 cites W2145142659 @default.
• W3207541583 cites W2146517905 @default.
• W3207541583 cites W2153651382 @default.
• W3207541583 cites W2162382402 @default.
• W3207541583 cites W2301335722 @default.
• W3207541583 cites W2316157625 @default.
• W3207541583 cites W2442856557 @default.
• W3207541583 cites W2742907857 @default.
• W3207541583 cites W2755955996 @default.
• W3207541583 cites W2762631272 @default.
• W3207541583 cites W2810423511 @default.
• W3207541583 cites W2811311151 @default.
• W3207541583 cites W2902086897 @default.
• W3207541583 cites W2913539314 @default.
• W3207541583 cites W2920406506 @default.
• W3207541583 cites W3006900496 @default.
• W3207541583 cites W3024628764 @default.
• W3207541583 doi "https://doi.org/10.2337/db21-0363" @default.
• W3207541583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34675003" @default.
• W3207541583 hasPublicationYear "2021" @default.
• W3207541583 type Work @default.
• W3207541583 sameAs 3207541583 @default.
• W3207541583 citedByCount "16" @default.
• W3207541583 countsByYear W32075415832022 @default.
• W3207541583 countsByYear W32075415832023 @default.
• W3207541583 crossrefType "journal-article" @default.
• W3207541583 hasAuthorship W3207541583A5001712204 @default.
• W3207541583 hasAuthorship W3207541583A5004975012 @default.
• W3207541583 hasAuthorship W3207541583A5005035675 @default.
• W3207541583 hasAuthorship W3207541583A5012131365 @default.
• W3207541583 hasAuthorship W3207541583A5013368285 @default.
• W3207541583 hasAuthorship W3207541583A5017941291 @default.
• W3207541583 hasAuthorship W3207541583A5022808077 @default.
• W3207541583 hasAuthorship W3207541583A5024153892 @default.
• W3207541583 hasAuthorship W3207541583A5024887366 @default.
• W3207541583 hasAuthorship W3207541583A5025869715 @default.
• W3207541583 hasAuthorship W3207541583A5025944032 @default.
• W3207541583 hasAuthorship W3207541583A5029784389 @default.
• W3207541583 hasAuthorship W3207541583A5033341142 @default.
• W3207541583 hasAuthorship W3207541583A5038746020 @default.
• W3207541583 hasAuthorship W3207541583A5062928937 @default.
• W3207541583 hasAuthorship W3207541583A5063307072 @default.
• W3207541583 hasAuthorship W3207541583A5066657162 @default.
• W3207541583 hasAuthorship W3207541583A5068420759 @default.
• W3207541583 hasAuthorship W3207541583A5069904410 @default.
• W3207541583 hasAuthorship W3207541583A5070188197 @default.
• W3207541583 hasBestOaLocation W32075415831 @default.
• W3207541583 hasConcept C106646824 @default.
• W3207541583 hasConcept C126322002 @default.
• W3207541583 hasConcept C134018914 @default.
• W3207541583 hasConcept C141359234 @default.

• next