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• W3207543998 abstract "Abstract In human neurodegenerative diseases, neurons undergo axonal degeneration months to years before they die. Here, we developed a system modelling early degenerative events in Drosophila adult photoreceptor cells. Thanks to the stereotypy of their axonal projections, this system delivers quantitative data on sporadic and progressive axonal degeneration of photoreceptor cells. Using this method, we show that exposure of adult flies to a constant light stimulation for several days overcomes the intrinsic resilience of R7 photoreceptors and leads to progressive axonal degeneration. This was not associated with apoptosis. We furthermore provide evidence that loss of synaptic integrity between R7 and a postsynaptic partner preceded axonal degeneration, thus recapitulating features of human neurodegenerative diseases. Finally, our experiments uncovered that neurotransmission to postsynaptic partners of R7 and their response are required to initiate degeneration, suggesting that postsynaptic cells signal back to the photoreceptor to maintain axonal structure. This model can be used to dissect cellular circuit mechanisms involved in the early events of axonal degeneration, allowing for a better understanding of how neurons cope with stress and lose their resilience capacities." @default.
• W3207543998 created "2021-10-25" @default.
• W3207543998 creator A5003860295 @default.
• W3207543998 creator A5038862163 @default.
• W3207543998 creator A5048041409 @default.
• W3207543998 creator A5049181790 @default.
• W3207543998 creator A5078297857 @default.
• W3207543998 creator A5083500202 @default.
• W3207543998 date "2021-10-15" @default.
• W3207543998 modified "2023-09-23" @default.
• W3207543998 title "A quantitative model of sporadic axonal degeneration in the <i>Drosophila</i> visual system" @default.
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