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- W3207558002 abstract "The use of dendritic cell (DC)-based cancer vaccines over three decades has shown them to be a safe therapeutic approach against a range of hematological and solid malignancies. However, underwhelming and inconsistent results from clinical trials have seen them move in and out of favor. The limitations of ex vivo generated monocyte-derived DC (MoDC) in these therapies provide a pointed explanation for the varying and somewhat disappointing clinical outcomes. The identification of a specialized role for the rare conventional type 1 dendritic cell (cDC1) subset in orchestrating tumor immunity via the initiation of CD8+ T cell responses has led to a new concept of targeting cDC1 as a therapeutic option to address the unmet need of enhancing the immune response in cancer patients.This article reviews several current challenges and key opportunities associated with the development and use of next generation cDC1 cancer vaccines.Manipulation of cDC1 quantity and quality holds enormous potential to improve tumor immunogenicity, as already demonstrated in preclinical models. New technologies are rapidly advancing the understanding of cDC1 in human cancer patients and facilitating the generation of these extremely rare cells in vitro, providing feasible new approaches toward clinical translation." @default.
- W3207558002 created "2021-10-25" @default.
- W3207558002 creator A5008582950 @default.
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- W3207558002 date "2021-10-26" @default.
- W3207558002 modified "2023-10-01" @default.
- W3207558002 title "Conventional type 1 dendritic cells (cDC1) as cancer therapeutics: challenges and opportunities" @default.
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- W3207558002 cites W1975655284 @default.
- W3207558002 cites W1976199086 @default.
- W3207558002 cites W1986543208 @default.
- W3207558002 cites W1988136067 @default.
- W3207558002 cites W1994993231 @default.
- W3207558002 cites W2010790611 @default.
- W3207558002 cites W2012574191 @default.
- W3207558002 cites W2023908963 @default.
- W3207558002 cites W2033899158 @default.
- W3207558002 cites W2033937518 @default.
- W3207558002 cites W2036240332 @default.
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- W3207558002 cites W2056330313 @default.
- W3207558002 cites W2068438013 @default.
- W3207558002 cites W2072956174 @default.
- W3207558002 cites W2088941703 @default.
- W3207558002 cites W2091403646 @default.
- W3207558002 cites W2095921413 @default.
- W3207558002 cites W2110974754 @default.
- W3207558002 cites W2113896298 @default.
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- W3207558002 cites W2138165953 @default.
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- W3207558002 doi "https://doi.org/10.1080/14712598.2022.1994943" @default.
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