Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207584617> ?p ?o ?g. }
- W3207584617 abstract "Mammalian chromosomes are three-dimensional entities shaped by converging and opposing forces. Mitotic cell division induces marked chromosome condensation, but following reentry into the G1 phase of the cell cycle, chromosomes reestablish their interphase organization. Here, we tested the role of RNA polymerase II (RNAPII) in this transition using a cell line that allows its auxin-mediated degradation. In situ Hi-C showed that RNAPII is required for both compartment and loop establishment following mitosis. RNAPs often counteract loop extrusion, and in their absence, longer and more prominent loops arose. Evidence from chromatin binding, super-resolution imaging, and in silico modeling allude to these effects being a result of RNAPII-mediated cohesin loading upon G1 reentry. Our findings reconcile the role of RNAPII in gene expression with that in chromatin architecture." @default.
- W3207584617 created "2021-10-25" @default.
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- W3207584617 date "2021-10-22" @default.
- W3207584617 modified "2023-10-03" @default.
- W3207584617 title "RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis" @default.
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- W3207584617 doi "https://doi.org/10.1126/sciadv.abg8205" @default.
- W3207584617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8535795" @default.
- W3207584617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34678064" @default.