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- W3207592101 abstract "Programmed death ligand 1 (PD-L1) is a typical immune surface protein that binds to programmed cell death 1 (PD-1) on T cells through its extracellular domain. Subsequently, T cell activity is inhibited, and tumor immune tolerance is enhanced. Anti-PD-1/PD-L1 immune checkpoint therapy blocks the combination of PD-1/PD-L1 and rejuvenates depleted T cells, thereby inhibiting tumor growth. Exosomes are biologically active lipid bilayer nanovesicles secreted by various cell types, which mediate signal communication between cells. Studies have shown that PD-L1 can not only be expressed on the surface of tumor cells, immune cells, and other cells in the tumor microenvironment, but also be released from tumor cells and exist in an extracellular form. In particular, exosome PD-L1 plays an unfavorable role in tumor immunosuppression. The immunomodulatory effect of exosome PD-L1 and its potential in fluid diagnosis have attracted our attention. This review aims to summarize the available evidence regarding the biological characteristics of exosome PD-L1 in tumor immunity, with a particular focus on the mechanisms in different cancers and clinical prospects. In addition, we also summarized the current possible and effective detection methods for exosome PD-L1 and proposed that exosome PD-L1 has the potential to become a target for overcoming anti-PD-1/PD-L1 antibody treatment resistance." @default.
- W3207592101 created "2021-10-25" @default.
- W3207592101 creator A5004273251 @default.
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- W3207592101 creator A5063253432 @default.
- W3207592101 creator A5081424082 @default.
- W3207592101 date "2021-10-15" @default.
- W3207592101 modified "2023-10-12" @default.
- W3207592101 title "Effects of Tumor-Derived Exosome Programmed Death Ligand 1 on Tumor Immunity and Clinical Applications" @default.
- W3207592101 cites W1500925570 @default.
- W3207592101 cites W150408279 @default.
- W3207592101 cites W1568317937 @default.
- W3207592101 cites W1762620449 @default.
- W3207592101 cites W1811917379 @default.
- W3207592101 cites W1846631206 @default.
- W3207592101 cites W1913780655 @default.
- W3207592101 cites W1966648901 @default.
- W3207592101 cites W1979140041 @default.
- W3207592101 cites W1983752521 @default.
- W3207592101 cites W1985844219 @default.
- W3207592101 cites W1993140699 @default.
- W3207592101 cites W1996145004 @default.
- W3207592101 cites W201042233 @default.
- W3207592101 cites W2012466427 @default.
- W3207592101 cites W2016983859 @default.
- W3207592101 cites W2025457001 @default.
- W3207592101 cites W2049078823 @default.
- W3207592101 cites W2049369927 @default.
- W3207592101 cites W2049717090 @default.
- W3207592101 cites W2062254683 @default.
- W3207592101 cites W2063264144 @default.
- W3207592101 cites W2068449976 @default.
- W3207592101 cites W2072462631 @default.
- W3207592101 cites W2095156669 @default.
- W3207592101 cites W2098259366 @default.
- W3207592101 cites W2100413206 @default.
- W3207592101 cites W2109298880 @default.
- W3207592101 cites W2109485845 @default.
- W3207592101 cites W2111217091 @default.
- W3207592101 cites W2111778115 @default.
- W3207592101 cites W2119091751 @default.
- W3207592101 cites W2124060252 @default.
- W3207592101 cites W2128384671 @default.
- W3207592101 cites W2136859769 @default.
- W3207592101 cites W2138352938 @default.
- W3207592101 cites W2140380746 @default.
- W3207592101 cites W2145758395 @default.
- W3207592101 cites W2149252678 @default.
- W3207592101 cites W2155464214 @default.
- W3207592101 cites W2165948908 @default.
- W3207592101 cites W2168083201 @default.
- W3207592101 cites W2171000684 @default.
- W3207592101 cites W2176647747 @default.
- W3207592101 cites W2198093519 @default.
- W3207592101 cites W2219050650 @default.
- W3207592101 cites W2292821496 @default.
- W3207592101 cites W2293531514 @default.
- W3207592101 cites W2307984341 @default.
- W3207592101 cites W2338494814 @default.
- W3207592101 cites W2340636398 @default.
- W3207592101 cites W2346239414 @default.
- W3207592101 cites W2347070489 @default.
- W3207592101 cites W2461138374 @default.
- W3207592101 cites W2465860350 @default.
- W3207592101 cites W2504822853 @default.
- W3207592101 cites W2509486054 @default.
- W3207592101 cites W2535485523 @default.
- W3207592101 cites W2570190993 @default.
- W3207592101 cites W2586804218 @default.
- W3207592101 cites W2603029028 @default.
- W3207592101 cites W2605377619 @default.
- W3207592101 cites W2605920833 @default.
- W3207592101 cites W2619454739 @default.
- W3207592101 cites W2738491178 @default.
- W3207592101 cites W2739501186 @default.
- W3207592101 cites W2741886782 @default.
- W3207592101 cites W2743022421 @default.
- W3207592101 cites W2745901392 @default.
- W3207592101 cites W2766514075 @default.
- W3207592101 cites W2767287110 @default.
- W3207592101 cites W2772306649 @default.
- W3207592101 cites W2772391116 @default.
- W3207592101 cites W2774491730 @default.
- W3207592101 cites W2786514708 @default.
- W3207592101 cites W2789588846 @default.
- W3207592101 cites W2790574591 @default.
- W3207592101 cites W2793011605 @default.
- W3207592101 cites W2793992337 @default.
- W3207592101 cites W2797309423 @default.
- W3207592101 cites W2809724091 @default.
- W3207592101 cites W2883384367 @default.
- W3207592101 cites W2884198871 @default.
- W3207592101 cites W2887249435 @default.