FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3207617048> ?p ?o ?g. }

• W3207617048 endingPage "103296" @default.
• W3207617048 startingPage "103296" @default.
• W3207617048 abstract "Autophagy is a conserved biological process that maintains cell homeostasis by targeting macromolecules for lysosome-mediated degradation. The levels of autophagy are relatively lower under normal conditions than under stress conditions (e.g., starvation), as autophagy is usually stimulated after multiple stresses. However, many autophagy-related regulators are still expressed under normal conditions. Although these regulators have been studied deeply in autophagy regulation, the nonautophagic roles of these regulators under normal conditions remain incompletely understood. Here, we found that autophagy-related 5 (ATG5), which is a key regulator of autophagy, regulates c-Myc protein degradation under normal conditions through the ubiquitin-proteasome pathway. We also found that ATG5 binds c-Myc and recruits the E3 ubiquitin-protein ligase FBW7 to promote c-Myc degradation. Moreover, ATG5-mediated degradation of c-Myc limits cell growth under normal conditions and is essential for embryonic stem cell differentiation. Therefore, this study reveals a nonautophagic role of ATG5 in regulating of c-Myc protein degradation." @default.
• W3207617048 created "2021-10-25" @default.
• W3207617048 creator A5005628069 @default.
• W3207617048 creator A5008716861 @default.
• W3207617048 creator A5024265456 @default.
• W3207617048 creator A5028206437 @default.
• W3207617048 creator A5029640741 @default.
• W3207617048 creator A5031268267 @default.
• W3207617048 creator A5042328954 @default.
• W3207617048 creator A5044475779 @default.
• W3207617048 creator A5065354071 @default.
• W3207617048 creator A5072042791 @default.
• W3207617048 creator A5080141160 @default.
• W3207617048 creator A5083283473 @default.
• W3207617048 creator A5090217472 @default.
• W3207617048 date "2021-11-01" @default.
• W3207617048 modified "2023-10-15" @default.
• W3207617048 title "A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation" @default.
• W3207617048 cites W1526993239 @default.
• W3207617048 cites W1538085254 @default.
• W3207617048 cites W1965254413 @default.
• W3207617048 cites W1965723162 @default.
• W3207617048 cites W1968444524 @default.
• W3207617048 cites W1969108502 @default.
• W3207617048 cites W1974868752 @default.
• W3207617048 cites W1975915706 @default.
• W3207617048 cites W1992532731 @default.
• W3207617048 cites W1994830470 @default.
• W3207617048 cites W2007314953 @default.
• W3207617048 cites W2023981106 @default.
• W3207617048 cites W2025364264 @default.
• W3207617048 cites W2034894297 @default.
• W3207617048 cites W2044724807 @default.
• W3207617048 cites W2047721594 @default.
• W3207617048 cites W2087988002 @default.
• W3207617048 cites W2097774235 @default.
• W3207617048 cites W2100434800 @default.
• W3207617048 cites W2135954438 @default.
• W3207617048 cites W2137434813 @default.
• W3207617048 cites W2148281700 @default.
• W3207617048 cites W2157096314 @default.
• W3207617048 cites W2166430233 @default.
• W3207617048 cites W2626062067 @default.
• W3207617048 cites W2752503197 @default.
• W3207617048 cites W2887067858 @default.
• W3207617048 cites W2897233009 @default.
• W3207617048 cites W2904357539 @default.
• W3207617048 cites W2945110877 @default.
• W3207617048 cites W2970743598 @default.
• W3207617048 cites W2983330781 @default.
• W3207617048 cites W2998173680 @default.
• W3207617048 cites W3083822497 @default.
• W3207617048 cites W3091837380 @default.
• W3207617048 cites W3092966039 @default.
• W3207617048 cites W4236967220 @default.
• W3207617048 doi "https://doi.org/10.1016/j.isci.2021.103296" @default.
• W3207617048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8564121" @default.
• W3207617048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34755101" @default.
• W3207617048 hasPublicationYear "2021" @default.
• W3207617048 type Work @default.
• W3207617048 sameAs 3207617048 @default.
• W3207617048 citedByCount "5" @default.
• W3207617048 countsByYear W32076170482022 @default.
• W3207617048 countsByYear W32076170482023 @default.
• W3207617048 crossrefType "journal-article" @default.
• W3207617048 hasAuthorship W3207617048A5005628069 @default.
• W3207617048 hasAuthorship W3207617048A5008716861 @default.
• W3207617048 hasAuthorship W3207617048A5024265456 @default.
• W3207617048 hasAuthorship W3207617048A5028206437 @default.
• W3207617048 hasAuthorship W3207617048A5029640741 @default.
• W3207617048 hasAuthorship W3207617048A5031268267 @default.
• W3207617048 hasAuthorship W3207617048A5042328954 @default.
• W3207617048 hasAuthorship W3207617048A5044475779 @default.
• W3207617048 hasAuthorship W3207617048A5065354071 @default.
• W3207617048 hasAuthorship W3207617048A5072042791 @default.
• W3207617048 hasAuthorship W3207617048A5080141160 @default.
• W3207617048 hasAuthorship W3207617048A5083283473 @default.
• W3207617048 hasAuthorship W3207617048A5090217472 @default.
• W3207617048 hasBestOaLocation W32076170481 @default.
• W3207617048 hasConcept C104317684 @default.
• W3207617048 hasConcept C134459356 @default.
• W3207617048 hasConcept C181199279 @default.
• W3207617048 hasConcept C185592680 @default.
• W3207617048 hasConcept C190283241 @default.
• W3207617048 hasConcept C203522944 @default.
• W3207617048 hasConcept C25602115 @default.
• W3207617048 hasConcept C27740335 @default.
• W3207617048 hasConcept C2780216420 @default.
• W3207617048 hasConcept C2781000418 @default.
• W3207617048 hasConcept C2992195973 @default.
• W3207617048 hasConcept C55493867 @default.
• W3207617048 hasConcept C62112901 @default.
• W3207617048 hasConcept C6929976 @default.
• W3207617048 hasConcept C86803240 @default.
• W3207617048 hasConcept C95444343 @default.
• W3207617048 hasConceptScore W3207617048C104317684 @default.
• W3207617048 hasConceptScore W3207617048C134459356 @default.
• W3207617048 hasConceptScore W3207617048C181199279 @default.

• next