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- W3207619085 endingPage "147687" @default.
- W3207619085 startingPage "147687" @default.
- W3207619085 abstract "Multiple Sclerosis (MS) is a neurodegenerative disease in which pathophysiology and symptom progression presents differently between the sexes. In a cohort of people with MS (n = 110), we used transcranial magnetic stimulation (TMS) to investigate sex differences in corticospinal excitability (CSE) and sex-specific relationships between CSE and cognitive function. Although demographics and disease characteristics did not differ between sexes, males were more likely to have cognitive impairment as measured by the Montreal Cognitive Assessment (MoCA); 53.3% compared to females at 26.3%. Greater CSE asymmetry was noted in females compared to males. Females demonstrated higher active motor thresholds and longer silent periods in the hemisphere corresponding to the weaker hand which was more typical of hand dominance patterns in healthy individuals. Males, but not females, exhibited asymmetry of nerve conduction latency (delayed MEP latency in the hemisphere corresponding to the weaker hand). In males, there was also a relationship between delayed onset of ipsilateral silent period (measured in the hemisphere corresponding to the weaker hand) and MoCA, suggestive of cross-callosal disruption. Our findings support that a sex-specific disruption in CSE exists in MS, pointing to interhemispheric disruption as a potential biomarker of cognitive impairment and target for neuromodulating therapies." @default.
- W3207619085 created "2021-10-25" @default.
- W3207619085 creator A5021135448 @default.
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- W3207619085 creator A5048719144 @default.
- W3207619085 creator A5056497243 @default.
- W3207619085 creator A5071157557 @default.
- W3207619085 date "2021-12-01" @default.
- W3207619085 modified "2023-09-27" @default.
- W3207619085 title "Sex-specific disruption in corticospinal excitability and hemispheric (a)symmetry in multiple sclerosis" @default.
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