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• W3207637518 endingPage "264" @default.
• W3207637518 startingPage "246" @default.
• W3207637518 abstract "Mosquito host-seeking is mediated by attraction to physical and chemical cues released in the breath and by the skin. Most of the skin volatiles are produced by the host skin microbiota, and differences in microbiota composition correlate with human attractiveness. Quantitative and qualitative discrimination of skin volatiles may be an important driver of host preference for anthropogenic mosquito species. Differences in skin odor composition are detected by the peripheral olfactory system and discriminated by sequence and expression polymorphisms of olfactory receptors. Designing new repellents and re-engineering the human skin microbiota to alter the composition of the human scent may possibly reduce mosquito bites and prevent the spread of mosquito-borne diseases. Female mosquitoes use chemical and physical cues, including vision, smell, heat, and humidity, to orient toward hosts. Body odors are produced by skin resident bacteria that convert metabolites secreted in sweat into odorants that confer the characteristic body scent. Mosquitoes detect these compounds using olfactory receptors in their antennal olfactory receptor neurons. Such information is further integrated with the senses of temperature and humidity, as well as vision, processed in the brain into a behavioral output, leading to host finding. Knowledge of human scent components unveils a variety of odorants that are attractive to mosquitoes, but also odor-triggering repellency. Finding ways to divert human-seeking behavior by female mosquitoes using odorants can possibly mitigate mosquito-borne pathogen transmission. Female mosquitoes use chemical and physical cues, including vision, smell, heat, and humidity, to orient toward hosts. Body odors are produced by skin resident bacteria that convert metabolites secreted in sweat into odorants that confer the characteristic body scent. Mosquitoes detect these compounds using olfactory receptors in their antennal olfactory receptor neurons. Such information is further integrated with the senses of temperature and humidity, as well as vision, processed in the brain into a behavioral output, leading to host finding. Knowledge of human scent components unveils a variety of odorants that are attractive to mosquitoes, but also odor-triggering repellency. Finding ways to divert human-seeking behavior by female mosquitoes using odorants can possibly mitigate mosquito-borne pathogen transmission. feeding on humans. attraction to and/or preference for feeding on humans. attraction to and/or preference for humans and other animals. a protein subunit that pairs with other receptors’ subunits, assembling into fully functional receptors. a molecular technique that modifies the genetic material by means of deletions (knockouts) and insertions of specific DNA sequences (knockins). genetic components responsible for controlling gene expression, such as promoters and enhancers. Promoters can be inserted into the genetic material (gene editing) to control the expression of exogenous genes (knockins). structures of the antennal lobes where synapses form between olfactory receptor neurons, projection neurons, and local interneurons. Whereas local interneurons have modulatory roles, projection neurons transmit the signals to the higher brain centers. weakening of behavioral responses due to repeated stimulation. blood warmed at the human body temperature (37°C) and offered to mosquitoes using feeding devices. regions of the insect brain responsible for learning and memory (mushroom bodies) and innate behavior (lateral horn). chemical cues released by an animal species that evoke mosquito behavioral responses. the range of host species a mosquito species is typically attracted to and/or feeds on. the degree of selectivity exhibited by a mosquito species in choosing a host. the association of an odorant with a reward, leading to increased behavioral responses towards such an odorant. the set of sensory neurons that perceive odorants in the antennae’ sensilla and transmit the information to other brain centers. each olfactory receptor neuron expresses an individual tuning receptor along with a coreceptor, which is also shared with many other ORNs. the set of sensilla and their housed ORNs that mediate the detection of kairomones and pheromones. the brain structures where input sensory information is received. the microbes (viruses, fungi, and bacteria) covering the skin surface and associated structures (hair follicles, sebaceous glands, and sweat glands). the human emanations extracted from skin (volatile bouquet) by different sampling techniques. when responses to two stimuli are stronger than the sum of the responses to each individual stimulus. unique receptor subunits that pair with a shared coreceptor, forming the functional odor receptor. odor valance refers to the spectrum of behavioral responses evoked by an odorant-based stimulus. attraction to and/or preference for feeding on (nonhuman) species. feeding on (non-human) species." @default.
• W3207637518 created "2021-10-25" @default.
• W3207637518 creator A5019596404 @default.
• W3207637518 creator A5037711069 @default.
• W3207637518 creator A5043476870 @default.
• W3207637518 date "2022-03-01" @default.
• W3207637518 modified "2023-10-16" @default.
• W3207637518 title "Human attractive cues and mosquito host-seeking behavior" @default.
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